Anti-Caspase-9 (phospho-T125) CASP9 Antibody
Boster Bio Anti-Caspase-9 (phospho-T125) CASP9 Antibody catalog # A00080T125. Tested in IHC applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
Caspase-9; CASP-9;3.4.22.62
Gene Name
CASP9
UniProt
P55211
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic phosphopeptide derived from human Caspase-9 around the phosphorylation site of Threonine 125.
Clonality
Polyclonal
Tissue Specificity
Ubiquitous, with highest expression in the heart, moderate expression in liver, skeletal muscle, and pancreas. Low levels in all other tissues. Within the heart, specifically expressed in myocytes.
Applications
IHC
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Concentration
1 mg/mL
Form
Liquid
Function
Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf- 1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly (ADP- ribose) polymerase (PARP) .
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
46281 MW
Applications Notes
IHC: 1:50-1:200
Gene Name Synonym
Caspase-9
Protein Name
Caspase-9
Contents
Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
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