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Anti-TRICK2 Antibody

Rabbit Polyclonal Antibody specific to TRICK2 (DR5,TRAIL-R2)

Product Specifications

Product Name Alternative

Death receptor 5, TNF-related apoptosis-inducing ligand receptor 2, TRAIL receptor 2, TRAIL-R2, CD antigen CD262

Gene Name

TNFRSF10B

Gene ID

8795

NCBI Gene ID

<a href="https://www.ncbi.nlm.nih.gov/gene/?term=TNFRSF10B">TNFRSF10B</a>

UniProt

O14763

Accession Number

NP_003833.4

Cellular Locus

Membrane; Single-pass type I membrane protein.

Host

Rabbit

Reactivity

Human

Immunogen

Synthetic peptide corresponding to amino acids 309-325 (EHLLEPAEAERSQRRRL, isoform 1) of human TRICK2 precursor conjugated to KLH at the N-terminus. The same sequence is found in isoform 2 at amino acids 280-296.

Target Antigen

Tumor necrosis factor receptor superfamily member 10B

Target

TRICK2

Clonality

Polyclonal

Type

Antibody

Applications

WB, ELISA

Field of Research

Apoptosis

Purification Method

Purified by peptide immuno-affinity chromatography

Concentration

Lot Specific

Dilution

Dilute in PBS or medium which is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Phosphate Buffered Saline

Function

Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:10549288). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis. {PubMed:10542098, PubMed:10549288, PubMed:15322075}.

Additionnal Information

Immunoblotting: use at 1:500 dilution. A band of approximately 57 kDa is detected. <br><br>Positive control: whole cell lysate from HL60, HeLa, or Jurkat cells.

Storage Conditions

This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze- thaw cycles.

Product Datasheet

https://www.qedbio.com/wp-content/uploads/pdf/11092x.pdf

Specificity

This antibody recognizes human TRICK2.

Formulation

PBS, pH 7.4.

Buffer pH

pH 7.4

Target Background

Apoptosis is induced by cytokines in the TNF family through their death domain containing receptors. TRICK2 (TRAIL receptor inducer of cell killing 2) is a member of the TNF receptor family and contains the conserved death domain. TRICK2 is expressed at high levels in lymphocytes and spleen cells and in many types of tumor cells. Overexpression of TRICK2 rapidly induces cell death by apoptosis. TRICK2 has been shown to function as a receptor for TRAIL and can inhibit TRAIL-induced killing of lymphocytic cells. Other names for TRICK2 include DR5, Apo2, TRAIL-R2, and KILLER.

CAS Number

9007-83-4

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