Anti-LGP2/DHX58 Antibody Picoband®

Enables several functions, including ATP hydrolysis activity; RNA binding activity; and zinc ion binding activity. Involved in negative regulation of type I interferon production and regulation of innate immune response. Predicted to be active in cytoplasm.

DHX58; D11LGP2E; LGP2; Probable ATP-dependent RNA helicase DHX58; EC 3.6.4.13; Probable ATP-dependent helicase LGP2; Protein D11Lgp2 homolog; RIG-I-like receptor 3; RLR-3; RIG-I-like receptor LGP2; RLR

E.coli-derived human LGP2/DHX58 recombinant protein (Position: A38-S658) . Human LGP2/DHX58 shares 78.4% amino acid (aa) sequence identity with mouse LGP2/DHX58.

1. Cui, Y., Li, M., Walton, K. D., Sun, K., Hanover, J. A., Furth, P. A., Hennighausen, L. The Stat3/5 locus encodes novel endoplasmic reticulum and helicase-like proteins that are preferentially expressed in normal and neoplastic mammary tissue. Genomics 78: 129-134, 2001. 2. Miyoshi, K., Cui, Y., Riedlinger, G., Robinson, P., Lehoczky, J., Zon, L., Oka, T., Dewar, K., Hennighausen, L. Structure of the mouse Stat 3/5 locus: evolution from Drosophila to zebrafish to mouse. Genomics 71: 150-155, 2001. 3. Saito, T., Hirai, R., Loo, Y.-M., Owen, D., Johnson, C. L., Sinha, S. C., Akira, S., Fujita, T., Gale, M., Jr. Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2. Proc. Nat. Acad. Sci. 104: 582-587, 2007.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.