CACNA1C Rabbit Polyclonal Antibody
Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm. Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group (Probable).
Product Specifications
CAS Number
9007-83-4
Product Name Alternative
Abbreviation
CACNA1C, CACH2, CACN2, CACNL1A1, CCHL1A1
Swiss Prot
Q13936 Human, Q01815 Mouse, P22002 Rat
Cellular Locus
Plasma membrane.
Host
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthetic peptide within mouse CACNA1C aa 802-851 / 2,139.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
Dot Blot, IF-Cell, IHC-P, FC
Positive Control
SiHa, SKOV-3, rat brain tissue, human kidney tissue, human uterus tissue, mouse heart tissue.
Concentration
1 mg/mL
Dilution
Dot Blot: 1:500-1:1,000;IF-Cell: 1:500-1:2,000;IHC-P: 1:50-1:200;FC: 1:50-1:100
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 249 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No
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