TD-106
TD-106 is a cereblon (CRBN) modulator, which can be used for targeted protein degradation. BRD4 PROTACs with TD-106 induce BRD4 degradation[1].
Product Specifications
CAS Number
[2250288-69-6]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Ligands for E3 Ligase
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/TD-106.html
Purity
99.81
Solubility
DMSO : ≥ 125 mg/mL
Smiles
NC1=CC=CC(N=NN2C3CCC(NC3=O)=O)=C1C2=O
Molecular Formula
C12H11N5O3
Molecular Weight
273.25
Precautions
H302, H315, H319, H335
References & Citations
[1]Kim SA, et al. A novel cereblon modulator for targeted protein degradation. Eur J Med Chem. 2019 Mar 15;166:65-74.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS6181519-01 0.1 mL
CNOT7 (CCR4-NOT Transcription Complex, Subunit 7, CAF1, hCAF-1) (HRP)
Ask
View Details MBS6181519-02 5x 0.1 mL
CNOT7 (CCR4-NOT Transcription Complex, Subunit 7, CAF1, hCAF-1) (HRP)
Ask
View Details