TD-106
TD-106 is a cereblon (CRBN) modulator, which can be used for targeted protein degradation. BRD4 PROTACs with TD-106 induce BRD4 degradation[1].
Product Specifications
CAS Number
2250288-69-6
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Ligands for E3 Ligase
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/TD-106.html
Purity
99.81
Solubility
DMSO : ≥ 125 mg/mL
Smiles
NC1=CC=CC(N=NN2C3CCC(NC3=O)=O)=C1C2=O
Molecular Formula
C12H11N5O3
Molecular Weight
273.25
Precautions
H302, H315, H319, H335
References & Citations
[1]Kim SA, et al. A novel cereblon modulator for targeted protein degradation. Eur J Med Chem. 2019 Mar 15;166:65-74.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
Available Sizes
Frequently Asked Questions
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