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Anti-STAT2 Rabbit Monoclonal Antibody

Boster Bio Anti-STAT2 Rabbit Monoclonal Antibody catalog # M01360. Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Signal transducer and activator of transcription 2; p113; STAT2

Gene Name

STAT2

Gene ID

6773

UniProt

P52630

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A synthesized peptide derived from human STAT2

Clonality

Monoclonal

Clone

Clone: HCB-19

Tissue Specificity

Expressed in endoderm, intestinal epithelial cells and in most extraembryonic tissues. .

Applications

WB, IHC, ICC, IF

Field of Research

Epigenetics and Nuclear Signaling, Nuclear Signaling, Nuclear Signaling Pathways, Signal Transduction, Signaling Pathway, Transcription

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta) . Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

97916 MW

Observed Molecular Weight

48 kDa

Gene Name Synonym

Signal transducer and activator of transcription 2

Subcellular Location

Cytoplasm. Nucleus. Translocated into the nucleus upon activation by IFN-alpha/beta.

Protein Name

Glycogen synthase kinase-3 beta (gsk3b)

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

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