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Anti-IRAKM/IRAK3 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Interleukin-1 receptor-associated kinase 3, also called IRAK3 or IRAKM is an enzyme that in humans is encoded by the IRAK3 gene. The IRAKM gene consists of 12 exons spanning a region of approximately 60 kb in chromosome 12q14.3. This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma.

Synonyms

Interleukin-1 receptor-associated kinase 3; IRAK-3;2.7.11.1; IL-1 receptor-associated kinase M; IRAK-M; IRAK3

Gene Name

IRAK3

Gene ID

11213

UniProt

Q9Y616

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human IRAKM.

Clonality

Polyclonal

Tissue Specificity

Expressed predominantly in peripheral blood lymphocytes. .

Applications

Flow Cytometry

Field of Research

Cytokines, Immunology, Innate Immunity, Interleukins, Protein Phosphorylation, Ser/Thr Kinases, Signal Transduction, TLR Signaling

Purification

Immunogen affinity purified.

Form

Liquid

Function

Inhibits dissociation of IRAK1 and IRAK4 from the Toll- like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex. .

References & Citations

1. Balaci, L., Spada, M. C., Olla, N., Sole, G., Loddo, L., Anedda, F., Naitza, S., Zuncheddu, M. A., Maschio, A., Altea, D., Uda, M., Pilia, S., and 30 others. IRAK-M is involved in the pathogenesis of early-onset persistent asthma. Am. J. Hum. Genet. 80: 1103-1114, 2007. 2. Deng, J. C., Cheng, G., Newstead, M. W., Zeng, X., Kobayashi, K., Flavell, R. A., Standiford, T. J. Sepsis-induced suppression of lung innate immunity is mediated by IRAK-M. J. Clin. Invest. 116: 2532-2542, 2006. 3. Kobayashi, K., Hernandez, L. D., Galan, J. E., Janeway, C. A., Jr., Medzhitov, R., Flavell, R. A. IRAK-M is a negative regulator of Toll-like receptor signaling. Cell 110: 191-202, 2002.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

67767 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Interleukin-1 receptor-associated kinase 3

Subcellular Location

Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.

Sequence Similarities

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.

Protein Name

Interleukin-1 receptor-associated kinase 3

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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