Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-Caspase-12/CASP12 Antibody Picoband®

Boster Bio Anti-Caspase-12/CASP12 Antibody catalog # PA2103. Tested in IHC, WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

Caspase 12 is an enzyme known as a cysteine protease. It belongs to a family of enzymes called caspases that cleave their substrates at C-terminal aspartic acid residues. The CASP12 gene was mapped to chromosome 11q22.3. Csp12L attenuates the inflammatory and innate immune response to endotoxins and in doing so may constitute a risk factor for developing sepsis. The estrogen-mediated inhibition of CSP12L expression is a built-in mechanism that has evolved to protect females from infection by favoring a more robust inflammatory response to pathogens, perhaps notably in childbirth.

Synonyms

Inactive caspase-12; CASP-12; CASP12; UNQ9415/PRO34398

Gene Name

CASP12

Gene ID

100506742

UniProt

Q6UXS9

Host

Rabbit

Reactivity

Human, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human Caspase-12.

Clonality

Polyclonal

Tissue Specificity

Detected in heart, kidney, liver, lung, pancreas, small intestine, spleen, stomach, thymus and testis. .

Applications

IHC, WB

Field of Research

Apoptosis, Cell Biology, Intracellular

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Has no protease activity. May reduce cytokine release in response to bacterial lipopolysaccharide during infections. Reduces activation of NF-kappa-B in response to TNF. .

References & Citations

1. Fischer, H., Koenig, U., Eckhart, L., Tschachler, E. Human caspase 12 has acquired deleterious mutations. Biochem. Biophys. Res. Commun. 293: 722-726, 2002. 2. Saleh, M., Mathison, J. C., Wolinski, M. K., Bensinger, S. J., Fitzgerald, P., Droin, N., Ulevitch, R. J., Green D. R., Nicholson, D. W. Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice. Nature 440: 1064-1068, 2006. 3. Yeretssian, G., Doiron, K., Shao, W., Leavitt, B. R., Hayden, M. R., Nicholson, D. W., Saleh, M. Gender differences in expression of the human caspase-12 long variant determines susceptibility to Listeria monocytogenes infection. Proc. Nat. Acad. Sci. 106: 9016-9020, 2009.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

38865 MW

Observed Molecular Weight

39 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Inactive caspase-12

Subcellular Location

Cytoplasm.

Sequence Similarities

Belongs to the peptidase C14A family.

Protein Name

Inactive caspase-12

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

GRASP55 (Golgi reassembly-stacking Protein 2, GRS2, Golgi Phosphoprotein 6, GOLPH6, GRASP55, GORASP2) discontinued
223062-01 50 µL

GRASP55 (Golgi reassembly-stacking Protein 2, GRS2, Golgi Phosphoprotein 6, GOLPH6, GRASP55, GORASP2) discontinued

Ask
View Details
GRASP55 (Golgi reassembly-stacking Protein 2, GRS2, Golgi Phosphoprotein 6, GOLPH6, GRASP55, GORASP2) discontinued
223062-02 100 µL

GRASP55 (Golgi reassembly-stacking Protein 2, GRS2, Golgi Phosphoprotein 6, GOLPH6, GRASP55, GORASP2) discontinued

Ask
View Details
Mouse Monoclonal Notch-1 Antibody (527425) [PE/Atto594]
FAB5317PEATT594 0.1 mL

Mouse Monoclonal Notch-1 Antibody (527425) [PE/Atto594]

Ask
View Details
Thyroid Stimulating Hormone (TSH) (PE)
T5400-13J-PE 100 µL

Thyroid Stimulating Hormone (TSH) (PE)

Ask
View Details
Cadherin-3 (CDH3) Antibody
abx129739-01 100 µL

Cadherin-3 (CDH3) Antibody

Ask
View Details
Cadherin-3 (CDH3) Antibody
abx129739-02 200 µL

Cadherin-3 (CDH3) Antibody

Ask
View Details