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Anti-Desmoglein 3/DSG3 Antibody Picoband® Fluoro488 Conjugated

Selected Variant

PA1567-Fluoro488

Size: 100 µg/Vial

Product Specifications

Background

Desmoglein3 is also known as PVA (Pemphigus Vulgaris Antigen) . Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are autoimmune diseases of the skin which have as target antigens 2 different members of the desmoglein subfamily of the desmosomal cadherins: pemphigus vulgaris antigen (PVA, or desmoglein-3) in the case of PV and desmoglein I in the case of PF. The DSG3 gene, like the genes for DSG1 and DSG2, is located on chromosome 18. The human DSG3 gene consists of 15 exons and spans more than 23 kb. DSG3 and DSG1 are the autoantigens of pemphigus vulgaris and pemphigus foliaceus, respectively. DSG3 and DSG1 are the target antigens in PNP, and IgG autoantibodies against DSG3 in PNP sera play a pathogenic role in the loss of keratinocyte adhesion and blistering.

Synonyms

Desmoglein-3;130 kDa pemphigus vulgaris antigen; PVA; Cadherin family member 6; DSG3; CDHF6

Gene Name

DSG3

Gene ID

1830

UniProt

P32926

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human Desmoglein 3.

Clonality

Polyclonal

Tissue Specificity

Epidermis, tongue, tonsil, esophagus and carcinomas.

Applications

Flow Cytometry

Field of Research

Cadherins, Cell Adhesion, Cytoskeleton/ECM, Extracellular Matrix, Signal Transduction, Structures

Purification

Immunogen affinity purified.

Form

Liquid

Function

Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.

References & Citations

1. Amagai, M., Klaus-Kovtun, V., Stanley, J. R.Autoantibodies against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion.Cell 67: 869-877, 1991. 2. Arnemann, J., Spurr, N. K., Buxton, R. S.The human gene (DSG3) coding for the pemphigus vulgaris antigen is, like the genes coding for the other two known desmogleins, assigned to chromosome 18.Hum. Genet. 89: 347-350, 1992. 3. Silos, S. A., Tamai, K., Li, K., Kivirikko, S., Kouba, D., Christiano, A. M., Uitto, J.Cloning of the gene for human pemphigus vulgaris antigen (desmoglein 3), a desmosomal cadherin.J. Biol. Chem. 271: 17504-17511, 1996.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

107533 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Desmoglein-3

Subcellular Location

Cell membrane ; Single-pass type I membrane protein . Cell junction, desmosome .

Sequence Similarities

Belongs to the SCF family.

Protein Name

Desmoglein-3

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Price

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