Anti-Fatty Acid Binding Protein 5/FABP5 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
FABP5, Fatty acid-binding protein, epidermal, is a protein that in humans is encoded by the FABP5 gene. This gene encodes the fatty acid binding protein found in epidermal cells, and was first identified as being upregulated in psoriasis tissue. It is mapped to 8q21.13. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. It is though that FABPs roles include fatty acid uptake, transport, and metabolism.
Synonyms
Fatty acid-binding protein, epidermal; Epidermal-type fatty acid-binding protein; E-FABP; Fatty acid-binding protein 5; Psoriasis-associated fatty acid-binding protein homolog; PA-FABP; FABP5
Gene Name
FABP5
Gene ID
2171
UniProt
Q01469
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human Fatty Acid Binding Protein 5.
Clonality
Polyclonal
Tissue Specificity
Keratinocytes; highly expressed in psoriatic skin.
Applications
Flow Cytometry
Field of Research
Cancer, Cardiovascular, Fatty Acid Oxidation, Fatty Acids, Lipid and Lipoprotein Metabolism, Lipid Metabolism, Lipids/Lipoproteins, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Redox Metabolism, Signal Transduction
Purification
Immunogen affinity purified.
Form
Liquid
Function
High specificity for fatty acids. Highest affinity for C18 chain length. Decreasing the chain length or introducing double bonds reduces the affinity. May be involved in keratinocyte differentiation.
References & Citations
1. Hertzel, A. V., Bernlohr, D. A.Cloning and chromosomal location of the murine keratinocyte lipid-binding protein gene.Gene 221: 235-243, 1998. 2. Siegenthaler, G., Hotz, R., Chatellard-Gruaz, D., Didierjean, L., Hellman, U., Saurat, J. H.Purification and characterization of the human epidermal fatty acid-binding protein: localization during epidermal cell differentiation in vivo and in vitro.Biochem J. 302: 363-371, 1994.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
15164 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Fatty acid-binding protein, epidermal
Subcellular Location
Cytoplasm.
Sequence Similarities
Belongs to the IAP family.
Protein Name
Fatty acid-binding protein, epidermal
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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