CD10 Recombinant Mouse Monoclonal Antibody [A1G3-R]

This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing.

Product Specifications

CAS Number

9000-83-3

Product Name Alternative

Atriopeptidase antibody CALLA antibody CD10 antibody CD10 antigen antibody Common acute lymphocytic leukemia antigen antibody DKFZp686O16152 antibody EC 3.4.24.11 antibody Enkephalinase antibody EPN antibody Membrane metallo endopeptidase (neutral endopeptidase, enkephalinase) antibody Membrane metallo endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10) antibody Membrane metallo endopeptidase antibody Membrane metallo endopeptidase variant 1 antibody Membrane metallo endopeptidase variant 2 antibody Membrane metalloendopeptidase antibody Membrane metalloendopeptidase neutral endopeptidase enkephalinase antibody Membrane metalloendopeptidase neutral endopeptidase enkephalinase CALLA CD10 antibody Membrane metalloendopeptidase variant 1 antibody Membrane metalloendopeptidase variant 2 antibody MGC126681 antibody MGC126707 antibody MME antibody NEP antibody NEP_HUMAN antibody Neprilysin antibody neprilysin-390 antibody neprilysin-411 antibody Neutral endopeptidase 24.11 antibody Neutral endopeptidase antibody Neutral endopeptidase, membrane-associated antibody SFE antibody Skin fibroblast elastase antibody

Abbreviation

Neprilysin Atriopeptidase Common acute lymphocytic leukemia antigen CALLA Enkephalinase Neutral endopeptidase 24.11 NEP Neutral endopeptidase Skin fibroblast elastase SFE CD10

Swiss Prot

P08473 Human, Q61391 Mouse, P07861 Rat

Cellular Locus

Cell membrane.

Host

Mouse

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthetic peptide within human CD10 aa 200-300.

Isotype

IgG1

Clone

A1G3-R

Conjugation

Non-conjugated

Type

Recombinant Mouse monoclonal Antibody

Applications

WB, IF-Cell, IHC-P

Positive Control

Daudi cell lysate, Ramos cell lysate, LNCaP cell lysate, mouse kidney tissue lysate, Raji, Ramos, human renal clear cell carcinoma tissue, human small intestine tissue, human kidney tissue, mouse kidney tissue, rat kidney tissue.