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Anti-Pro-epidermal growth factor EGF Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Epidermal growth factor (EGF) is a growth factor that plays an important role in the regulation of cell growth, proliferation and differentiation by binding to its receptor EGFR. EGF locus is mapped to 4q21-4qter. Human EGF is a 6045-Da protein with 53 amino acid residues and three intramolecular disulfide bones. EGF results in cellular proliferation, differentiation, and survival while plays an important physiological role in the maintenance of oro-esophageal and gastric tissue integrity.

Synonyms

Pro-epidermal growth factor; EGF; Epidermal growth factor; Egf

Gene Name

EGF

Gene ID

13645

UniProt

P01132

Host

Rabbit

Reactivity

Mouse

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of mouse EGF.

Clonality

Polyclonal

Tissue Specificity

Expressed on activated B-cells.

Applications

Flow Cytometry

Field of Research

Cancer, Cell Biology, Cell Cycle, Cell Differentiation, Growth Factors, Growth Factors/Hormones, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity) . .

References & Citations

1. Brissenden, J. E., Ullrich, A., Francke, U.Chromosomal mapping of loci for insulin-like growth factors I and II and for epidermal growth factor in man.Am. J. Hum. Genet.36: 133S-only, 1984. 2. Carpenter G, Cohen S (May 1990) . Epidermal growth factor. The Journal of Biological Chemistry 265 (14) : 7709–12. 3. Herbst RS (2004) . Review of epidermal growth factor receptor biology. International Journal of Radiation Oncology, Biology, Physics 59 (2 Suppl) : 21–6.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

133072 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Pro-epidermal growth factor

Subcellular Location

Membrane; Single-pass type I membrane protein.

Sequence Similarities

Contains 9 EGF-like domains.

Protein Name

Pro-epidermal growth factor (EGF)

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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