Indole-3-carbinol

Indole-3-carbinol (I3C) inhibits NF-κB activity and also is an Aryl hydrocarbon receptor (AhR) agonist, and an inhibitor of WWP1 (WW domain-containing ubiquitin E3 ligase 1) .

Product Specifications

CAS Number

[700-06-1]

Product Name Alternative

Indole-3-methanol

UNSPSC

12352005

Hazard Statement

H315, H319

Target

Aryl Hydrocarbon Receptor; E1/E2/E3 Enzyme; Endogenous Metabolite; NF-κB

Type

Natural Products

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Indole-3-carbinol.html

Purity

99.16

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OCC1=CNC2=C1C=CC=C2

Molecular Formula

C9H9NO

Molecular Weight

147.18

Precautions

H315, H319

References & Citations

[1]Mohammadi S, et al. Indole-3-carbinol induces G1 cell cycle arrest and apoptosis through aryl hydrocarbon receptor in THP-1 monocytic cell line.J Recept Signal Transduct Res. 2017 Oct;37 (5) :506-514.|[2]Safa M, et al. Indole-3-carbinol suppresses NF-κB activity and stimulates the p53 pathway in pre-B acute lymphoblastic leukemia cells. Tumour Biol. 2015 May;36 (5) :3919-30.|[3]Lee YR, et al. Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway. Science. 2019 May 17;364 (6441) . pii: eaau0159.