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Anti-LMBRD1 Antibody Picoband® APC Conjugated

Product Specifications

Background

This gene encodes a lysosomal membrane protein that may be involved in the transport and metabolism of cobalamin. This protein also interacts with the large form of the hepatitis delta antigen and may be required for the nucleocytoplasmic shuttling of the hepatitis delta virus. Mutations in this gene are associated with the vitamin B12 metabolism disorder termed, homocystinuria-megaloblastic anemia complementation type F.

Synonyms

LMBRD1; C6orf209; NESI; BM-021; CD001; MSTP044; Probable lysosomal cobalamin transporter; HDAg-L-interacting protein NESI; LMBR1 domain-containing protein 1; Nuclear export signal-interacting protein

Gene Name

LMBRD1

Gene ID

55788

UniProt

Q9NUN5

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human LMBRD1 recombinant protein (Position: D67-A540) . Human LMBRD1 shares 93.9% amino acid (aa) sequence identity with both mouse and rat LMBRD1.

Clonality

Polyclonal

Applications

Flow Cytometry

Purification

Immunogen affinity purified.

Form

Liquid

References & Citations

1. Buers, I., Pennekamp, P., Nitschke, Y., Lowe, C., Skryabin, B. V., Rutsch, F. Lmbrd1 expression is essential for the initiation of gastrulation. J. Cell. Molec. Med. 20: 1523-1533, 2016. 2. Dickinson, M. E., Flenniken, A. M., Ji, X., Teboul, L., Wong, M. D., White, J. K., Meehan, T. F., Weninger, W. J., Westerberg, H., Adissu, H., Baker, C. N., Bower, L., and 73 others. High-throughput discovery of novel developmental phenotypes. Nature 537: 508-514, 2016. Note: Erratum: Nature 551: 398 only, 2017. 3. Kawaguchi, K., Okamoto, T., Morita, M., Imanaka, T. Translocation of the ABC transporter ABCD4 from the endoplasmic reticulum to lysosomes requires the escort protein LMBD1. Sci. Rep. 6: 30183, 2016. Note: Electronic Article.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

61 kDa

Applications Notes

6

Gene Name Synonym

LMBR1 domain containing 1

Protein Name

Lysosomal cobalamin transport escort protein LMBD1

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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