Anti-PIP4K2B Antibody Picoband® HRP Conjugated

The protein encoded by this gene catalyzes the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. The encoded protein sequence does not show similarity to other kinases, but the protein does exhibit kinase activity. Additionally, the encoded protein interacts with p55 TNF receptor.

PIP4K2B; PIP5K2B; Phosphatidylinositol 5-phosphate 4-kinase type-2 beta; EC 2.7.1.149; 1-phosphatidylinositol 5-phosphate 4-kinase 2-beta; Diphosphoinositide kinase 2-beta; Phosphatidylinositol 5-phosphate 4-kinase type II beta; PI (5P 4-kinase type II beta; PIP4KII-beta; PtdIns (5P-4-kinase isoform 2-beta

E.coli-derived human PIP4K2B recombinant protein (Position: D116-K360) . Human PIP4K2B shares 98.8% and 97.6% amino acid (aa) sequence identity with mouse and rat PIP4K2B, respectively.

1. Castellino, A. M., Parker, G. J., Boronenkov, I. V., Anderson, R. A., Chao, M. V. A novel interaction between the juxtamembrane region of the p55 tumor necrosis factor receptor and phosphatidylinositol-4-phosphate 5-kinase. J. Biol. Chem. 272: 5861-5870, 1997. 2. Ciruela, A., Hinchliffe, K. A., Divecha, N., Irvine, R. F. Nuclear targeting of the beta isoform of type II phosphatidylinositol phosphate kinase (phosphatidylinositol 5-phosphate 4-kinase) by its alpha-helix 7. Biochem. J. 346: 587-591, 2000. 3. Lamia, K. A. Personal Communication. Boston, Mass. 8/26/2004.