SARA Recombinant Rabbit Monoclonal Antibody [JE63-65]
Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization. This gene encodes a double zinc finger motif-containing protein that participates in the transforming growth factor-beta (TGFB) signalling pathway. The encoded protein interacts directly with SMAD2 and SMAD3, and recruits SMAD2 to the TGFB receptor. There are multiple pseudogenes for this gene on chromosomes 2, 15, and X. Alternative splicing results in multiple transcript variants.
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Abbreviation
ZFYVE9
Swiss Prot
O95405 Human,
Cellular Locus
Early endosome membrane, Cytoplasm.
Host
Rabbit
Species Reactivity
Human,Rat
Immunogen
Synthetic peptide within human SARA aa 1-50/1,425.
Isotype
IgG
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB
Positive Control
HUVEC cell lysate, rat brain tissue lysate, Hela cell lysate, SiHa cell lysate, PC-3 cell lysate.
Concentration
1 mg/mL
Dilution
WB: 1:500-1,000
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 156 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
Yes
Frequently Asked Questions
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Prefilled 2.0ml tubes, Stainless Steel, 2.8mm Acid Washed, 50pk
