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Anti-CRBN Antibody Picoband® HRP Conjugated

Product Specifications

Background

Cereblon is a protein that in humans is encoded by the CRBN gene. This gene encodes a protein related to the Lon protease protein family. In rodents and other mammals this gene product is found in the cytoplasm localized with a calcium channel membrane protein, and is thought to play a role in brain development. Mutations in this gene are associated with autosomal recessive nonsyndromic cognitive disability. Multiple transcript variants encoding different isoforms have been found for this gene.

Synonyms

CRBN; AD-006; Protein cereblon

Gene Name

CRBN

Gene ID

51185

UniProt

Q96SW2

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human CRBN recombinant protein (Position: M1-H378) . Human CRBN shares 95% amino acid (aa) sequence identity with both mouse and rat CRBN.

Clonality

Polyclonal

Applications

WB, IHC, ELISA

Purification

Immunogen affinity purified.

Form

Liquid

References & Citations

1. Fischer, E. S., Bohm, K., Lydeard, J. R., Yang, H., Stadler, M. B., Cavadini, S., Nagel, J., Serluca, F., Acker, V., Lingaraju, G. M., Tichkule, R. B., Schebesta, M., and 9 others. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature 512: 49-53, 2014. 2. Higgins, J. J., Hao, J., Kosofsky, B. E., Rajadhyaksha, A. M. Dysregulation of large-conductance Ca (2+) -activated K (+) channel expression in nonsyndromal mental retardation due to a cereblon p.R419X mutation. Neurogenetics 9: 219-223, 2008. 3. Higgins, J. J., Pucilowska, J., Lombardi, R. Q., Rooney, J. P. A mutation in a novel ATP-dependent Lon protease gene in a kindred with mild mental retardation. Neurology 63: 1927-1931, 2004.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing.

Calculated Molecular Weight

51 kDa

Gene Name Synonym

Cereblon

Protein Name

Protein cereblon

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4.

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