Anti-CDKN2C Antibody Picoband®

Cyclin-dependent kinase 4 inhibitor C?is an?enzyme?that in humans is encoded by the?CDKN2C?gene. The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported.

1. Bai, F., Pei, X.-H., Godfrey, V. L., Xiong, Y. Haploinsufficiency of p18 (INK4c) sensitizes mice to carcinogen-induced tumorigenesis. Molec. Cell. Biol. 23: 1269-1277, 2003. 2. Blais, A., Labrie, Y., Pouliot, F., Lachance, Y., Labrie, C. Structure of the gene encoding the human cyclin-dependent kinase inhibitor p18 and mutational analysis in breast cancer. Biochem. Biophys. Res. Commun. 247: 146-153, 1998. 3. Guan, K.-L., Jenkins, C. W., Li, Y., Nichols, M. A., Wu, X., O'Keefe, C. L., Matera, A. G., Xiong, Y. Growth suppression by p18, a p16 (INK4/MTS1) - and p14 (INK4B/MTS2) -related CDK6 inhibitor, correlates with wild-type pRb function. Genes Dev. 8: 2939-2952, 1994.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.