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Anti-NUP107 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Nucleoporin 107 (Nup107) is a protein that in humans is encoded by the NUP107 gene. This gene encodes a member of the nucleoporin family. The protein is localized to the nuclear rim and is an essential component of the nuclear pore complex (NPC) . All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

Synonyms

Tissue factor pathway inhibitor 2; TFPI-2; Placental protein 5; PP5; TFPI2

Gene Name

NUP107

Gene ID

57122

UniProt

P57740

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human NUP107 recombinant protein (Position: K30-H790) .

Clonality

Polyclonal

Tissue Specificity

Umbilical vein endothelial cells, liver, placenta, heart, pancreas, and maternal serum at advanced pregnancy.

Applications

Flow Cytometry

Field of Research

Cardiovascular, Cell Biology, Protease Inhibitors, Proteolysis/Ubiquitin

Purification

Immunogen affinity purified.

Form

Liquid

Function

May play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa. Has no effect on thrombin. .

References & Citations

1. Alazami, A. M., Patel, N., Shamseldin, H. E., Anazi, S., Al-Dosari, M. S., Alzahrani, F., Hijazi, H., Alshammari, M., Aldahmesh, M. A., Salih, M. A., Faqeih, E., Alhashem, A., and 41 others. Accelerating novel candidate gene discovery in neurogenetic disorders via whole-exome sequencing of prescreened multiplex consanguineous families. Cell Rep. 10: 148-161, 2015. 2. Belgareh, N., Rabut, G., Bai, S. W., van Overbeek, M., Beaudouin, J., Daigle, N., Zatsepina, O. V., Pasteau, F., Labas, V., Fromont-Racine, M., Ellenberg, J., Doye, V. An evolutionarily conserved NPC subcomplex, which redistributes in part to kinetochores in mammalian cells. J. Cell. Biol. 154: 1147-1160, 2001. [PubMed: 11564755, images, related citations] [Full Text] 3. Bierzynska, A., McCarthy, H. J., Soderquest, K., Sen, E. S., Colby, E., Ding, W. Y., Nabhan, M. M., Kerecuk, L., Hegde, S., Hughes, D., Marks, S., Feather, S., and 11 others. Genomic and clinical profiling of a national nephrotic syndrome cohort advocates a precision medicine approach to disease management. Kidney Int. 91: 937-947, 2017.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

26934 MW

Applications Notes

6

Gene Name Synonym

Tissue factor pathway inhibitor 2

Subcellular Location

Secreted.

Protein Name

Tissue factor pathway inhibitor 2

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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