Anti-POLR3GL Antibody Picoband® Fluoro488 Conjugated

Polymerase (RNA) III (DNA ed) polypeptide G (32kD) -like also known as POLR3GL is a protein which in humans is encoded by the POLR3GL gene.Predicted to enable chromatin binding activity. Involved in transcription by RNA polymerase III. Located in nucleus. Part of RNA polymerase III complex.

Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.

1. Beauregard-Lacroix, E., Salian, S., Kim, H., Ehresmann, S., D'Amours, G., Gauthier, J., Saillour, V., Bernard, G., Mitchell, G. A., Soucy, J. F., Michaud, J. L., Campeau, PM. A variant of neonatal progeroid syndrome, or Wiedemann-Rautenstrauch syndrome, is associated with a nonsense variant in POLR3GL. Europ. J. Hum. Genet. 28: 461-468, 2020. 2. Haurie, V., Durrieu-Gaillard, S., Dumay-Odelot, H., Da Silva, D., Rey, C., Prochazkova, M., Roeder, R. G., Besser, D., Teichmann, M. Two isoforms of human RNA polymerase III with specific functions in cell growth and transformation. Proc. Nat. Acad. Sci. 107: 4176-4181, 2010. 3. Renaud, M., Praz, V., Vieu, E., Florens, L., Washburn, M. P., l'Hote, P., Hernandez, N. Gene duplication and neofunctionalization: POLR3G and POLR3GL. Genome Res. 24: 37-51, 2014.