RIP3 Recombinant Rabbit Monoclonal Antibody [PSH04-78]
Receptor-interacting serine/threonine-protein kinase 3 is an enzyme that is encoded by the RIPK3 gene in humans. The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. It contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce necroptosis by interaction with RIPK1 and MLKL in a protein complex termed the necrosome. Interactions between RIPK1 and RIPK3 also form a necrosome, which triggers apoptosis.
Product Specifications
Product Name Alternative
Abbreviation
RIPK3, RIP3
Swiss Prot
Q9Y572 Human
Cellular Locus
Cytoplasm, cytosol, Nucleus.
Host
Rabbit
Species Reactivity
Human
Immunogen
Synthetic peptide within human RIP3 aa 401-450 / 518.
Isotype
IgG
Clone
PSH04-78
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB, IHC-P
Positive Control
THP-1 cell lysate, HT-29 cell lysate, SK-Br-3 cell lysate, HT-29, human colon cancer tissue.
Concentration
1 mg/mL
Dilution
WB: 1:2,000 ;IHC-P: 1:2,000-1:5,000
Purity
Protein A affinity purified.
Form
Liquid
Buffer
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 57 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
Yes
CAS Number
9000-83-3
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