Anti-STPG2 Antibody Picoband® Fluoro647 Conjugated

STPG2 (sperm tail PG rich repeat containing 2) is a 459 amino acid protein that contains 9 STPGR (sperm-tail PG-rich) repeats in human, and a 561 amino acid protein containing 10 STPGR (sperm-tail PG-rich) repeats in mouse. The gene encoding STPG2 maps to human chromosome 4q22.3 and mouse chromosome 3 H1. Representing approximately 6% of the human genome, chromosome 4 contains nearly 900 genes. Notably, the Huntingtin gene, which is found to encode an expanded glutamine tract in cases of Huntington’s disease, is on chromosome 4. FGFR-3 is also encoded on chromosome 4 and has been associated with thanatophoric dwarfism, achondroplasia, Muenke syndrome and bladder cancer. Chromosome 4 is also tied to Ellis-van Creveld syndrome, methylmalonic acidemia and polycystic kidney disease. Chromosome 4 reportedly contains the largest gene deserts (regions of the genome with no protein encoding genes) and has one of the two lowest recombination frequencies of the human chromosomes.

1. Yakut, S. , Cetin, Z. , Clark, O. A. , Usta, M. F. , Berker, S. , & Luleci, G. . (2013) . Exceptional complex chromosomal rearrangement and microdeletions at the 4q22.3q23 and 14q31.1q31.3 regions in a patient with azoospermia. Gene, 512 (1), 157-160. 2. Jing, J. , Fridley, B. L. , Feng, Q. , Abo, R. P. , Abra, B. , & Anthony, B. , et al. (2013) . Genome-wide association study for biomarker identification of rapamycin and everolimus using a lymphoblastoid cell line system. Frontiers in Genetics, 4, 166-166. 3. Lamesch, P. , Li, N. , Milstein, S. , Fan, C. , & Tong, H. . (2007) . Horfeome v3.1: a resource of human open reading frames representing over 10,000 human genes. Genomics, 89 (3), 307-315.