Higenamine (Standard)
Higenamine (Norcoclaurine), a β2-AR agonist with antioxidant capability, is a key component of the Chinese herb aconite root that prescribes for treating symptoms of heart failure in the oriental Asian countries. Higenamine is also a α1-adrenergic receptor antagonist with hypotensive effect. is a selective LSD1 inhibitor (IC50=1.47 μM) that can be isolated from aconite. Higenamine hydrochloride has anti-inflammatory and antibacterial activity. Higenamine protects myocyte Apoptosis and ischemia/reperfusion (I/R) injury through selective activation of beta2-adrenergic receptor (β2-AR) . Higenamine also reduces I/R-induced myocardial infarction in mice. Higenamine can attenuate IL-1β-induced Apoptosis through ROS-mediated PI3K/Akt signaling pathway. Higenamine protects brain cells from oxygen deprivation. Higenamine can promote bone formation in osteoporosis through the SMAD2/3 pathway. Higenamine can be used to study cancer, inflammation, cardiorenal syndrome and other diseases[1][2][3][4][5][6][7][8][9][10][11].
Product Specifications
Product Name Alternative
Norcoclaurine (Standard) ; Demethyl-Coclaurine (Standard)
UNSPSC
12352005
Target
Adrenergic Receptor; Apoptosis; MAP3K; MDM-2/p53; ROS Kinase
Related Pathways
Apoptosis; GPCR/G Protein; MAPK/ERK Pathway; Neuronal Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Cardiovascular Disease; Endocrinology
Smiles
OC1=CC2=C(C(CC3=CC=C(O)C=C3)NCC2)C=C1O
Molecular Formula
C16H17NO3
Molecular Weight
271.31
References & Citations
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N2037R/
Scientific Category
Reference Standards
CAS Number
[5843-65-2]
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