What is the catalog number for Higenamine (Standard)?

The catalog number for Higenamine (Standard) is HY-N2037R.

What sizes are available for Higenamine (Standard)?

Higenamine (Standard) is available in the following size(s): 1 Each.

Is Higenamine (Standard) in stock?

Higenamine (Standard) is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Higenamine (Standard)?

Higenamine (Standard) is manufactured by QuantiMol.

What is the estimated delivery time for Higenamine (Standard)?

Estimated delivery time for Higenamine (Standard) is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Higenamine (Standard)?

The safety data sheet for Higenamine (Standard) is available here: http://file.medchemexpress.com/batch_PDF/HY-N2037R/.

Higenamine (Standard)

Higenamine (Norcoclaurine), a β2-AR agonist with antioxidant capability, is a key component of the Chinese herb aconite root that prescribes for treating symptoms of heart failure in the oriental Asian countries. Higenamine is also a α1-adrenergic receptor antagonist with hypotensive effect. is a selective LSD1 inhibitor (IC50=1.47 μM) that can be isolated from aconite. Higenamine hydrochloride has anti-inflammatory and antibacterial activity. Higenamine protects myocyte Apoptosis and ischemia/reperfusion (I/R) injury through selective activation of beta2-adrenergic receptor (β2-AR) . Higenamine also reduces I/R-induced myocardial infarction in mice. Higenamine can attenuate IL-1β-induced Apoptosis through ROS-mediated PI3K/Akt signaling pathway. Higenamine protects brain cells from oxygen deprivation. Higenamine can promote bone formation in osteoporosis through the SMAD2/3 pathway. Higenamine can be used to study cancer, inflammation, cardiorenal syndrome and other diseases[1][2][3][4][5][6][7][8][9][10][11].

Product Specifications

CAS Number

5843-65-2

Product Name Alternative

Norcoclaurine (Standard) ; Demethyl-Coclaurine (Standard)

UNSPSC

12352005

Target

Adrenergic Receptor; Apoptosis; MAP3K; MDM-2/p53; ROS Kinase

Related Pathways

Apoptosis; GPCR/G Protein; MAPK/ERK Pathway; Neuronal Signaling; Protein Tyrosine Kinase/RTK

Field of Research

Cardiovascular Disease; Endocrinology

Smiles

OC1=CC2=C(C(CC3=CC=C(O)C=C3)NCC2)C=C1O

Molecular Formula

C16H17NO3

Molecular Weight

271.31

References & Citations

[1]Wu MP, et al. Higenamine protects ischemia/reperfusion induced cardiac injury and myocyte apoptosis through activation of β2-AR/PI3K/AKT signaling pathway. Pharmacol Res. 2016 Feb;104:115-23.|[2]Lee SR, et al. Acute oral intake of a higenamine-based dietary supplement increases circulating free fatty acidsand energy expenditure in human subjects. Lipids Health Dis. 2013 Oct 21;12:148.|[3]Wen J, et al. Role of Higenamine in Heart Diseases: A Mini-Review. Front Pharmacol. 2022 Jan 10;12:798495. |[4]Chen DT, et al. Pharmacological effects of higenamine based on signalling pathways and mechanism of action. Front Pharmacol. 2022 Sep 15;13:981048. |[5]Romeo I, et al. The Antioxidant Capability of Higenamine: Insights from Theory. Antioxidants (Basel) . 2020 Apr 25;9 (5) :358.|[6]Fang Y, et al. Discovery of higenamine as a potent, selective and cellular active natural LSD1 inhibitor for MLL-rearranged leukemia therapy. Bioorg Chem. 2021 Apr;109:104723. |[7]Ha YM, et al. Higenamine reduces HMGB1 during hypoxia-induced brain injury by induction of heme oxygenase-1 through PI3K/Akt/Nrf-2 signal pathways. Apoptosis. 2012 May;17 (5) :463-74.|[8]Zhu X, et al. Higenamine mitigates interleukin-1β-induced human nucleus pulposus cell apoptosis by ROS-mediated PI3K/Akt signaling. Mol Cell Biochem. 2021 Nov;476 (11) :3889-3897.|[9]Deng T, et al. Higenamine Improves Cardiac and Renal Fibrosis in Rats With Cardiorenal Syndrome via ASK1 Signaling Pathway. J Cardiovasc Pharmacol. 2020 Jun;75 (6) :535-544. |[10]Erasto, Paul et al. Evaluation of Antimycobacterial Activity of Higenamine Using Galleria mellonella as an In Vivo Infection Model. Natural products and bioprospecting vol. 8,1 (2018) : 63-69. |[11]Dong, Hui et al. Higenamine Promotes Osteogenesis Via IQGAP1/SMAD4 Signaling Pathway and Prevents Age- and Estrogen-Dependent Bone Loss in Mice. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research vol. 38,5 (2023) : 775-791.