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Anti-gamma Synuclein/SNCG Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Gamma-synuclein is a protein that in humans is encoded by the SNCG gene. This gene encodes a member of the synuclein family of proteins which are believed to be involved in the pathogenesis of neurodegenerative diseases. Mutations in this gene have also been associated with breast tumor development.

Synonyms

Laminin subunit gamma-1; Laminin B2 chain; Laminin-1 subunit gamma; Laminin-10 subunit gamma; Laminin-11 subunit gamma; Laminin-2 subunit gamma; Laminin-3 subunit gamma; Laminin-4 subunit gamma; Laminin-6 subunit gamma; Laminin-7 subunit gamma; Laminin-8 subunit gamma; Laminin-9 subunit gamma; S-laminin subunit gamma; S-LAM gamma; Lamc1; Lamb-2, Lamc-1

Gene Name

SNCG

Gene ID

6623

UniProt

O76070

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human gamma Synuclein/SNCG, which shares 53.8% amino acid (aa) sequence identity with rat SNCG.

Clonality

Polyclonal

Tissue Specificity

Found in the basement membranes (major component) .

Applications

Flow Cytometry

Field of Research

Cytoskeleton/ECM, Extracellular Matrix, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

References & Citations

1. Ji, H., Liu, Y. E., Jia, T., Wang, M., Liu, J., Xiao, G., Joseph, B. K., Rosen, C., Shi, Y. E. Identification of a breast cancer-specific gene, BCSG1, by differential cDNA sequencing. Cancer Res. 57: 759-764, 1997. 2. Lavedan, C., Buchholtz, S., Auburger, G., Albin, R. L., Athanassiadou, A., Blancato, J., Burguera, J. A., Ferrell, R. E., Kostic, V., Leroy, E., Leube, B., Mota-Vieira, L., and 9 others. Absence of mutation in the beta- and gamma-synuclein genes in familial autosomal dominant Parkinson's disease. DNA Res. 5: 401-402, 1998. 3. Lavedan, C., Leroy, E., Dehejia, A., Buchholtz, S., Dutra, A., Nussbaum, R. L., Polymeropoulos, M. H. Identification, localization and characterization of the human gamma-synuclein gene. Hum. Genet. 103: 106-112, 1998.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

177298 MW

Applications Notes

6

Gene Name Synonym

Laminin subunit gamma-1

Subcellular Location

Secreted, extracellular space, extracellular matrix, basement membrane.

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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