AP-III-a4
Product Specifications
UNSPSC Description
AP-III-a4 (ENOblock) is a nonsubstrate analogue enolase inhibitor with an IC50 of 0.576 uM. AP-III-a4 can be used for the research of cancer and diabetic[1].
Target Antigen
Apoptosis; Enolase
Type
Reference compound
Related Pathways
Apoptosis;Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/ap-iii-a4.html
Solubility
DMSO : 100 mg/mL (ultrasonic)|H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
FC1=CC=C(CNC2=NC(NCC3CCCCC3)=NC(NC4=CC=C(CC(NCCOCCOCCN)=O)C=C4)=N2)C=C1
Molecular Weight
594.72
References & Citations
[1]Da-Woon Jung, et al. A Unique Small Molecule Inhibitor of Enolase Clarifies Its Role in Fundamental Biological Processes.ACS Chem. Biol., 2013, 8 (6), pp 1271–1282Biomed Pharmacother. 2024 Jun 18:177:116970.|bioRxiv. 2024 October 25.|Cancer Cell. 2024 Aug 12;42(8):1386-1400.e8.|Cell Discov. 2020 Aug 18;6:56.|Research Square Print. November 14th, 2022|SSRN. 2023 Feb 10.|Theranostics. 2019 Aug 12;9(20):5769-5783.|Cancers (Basel). 2020 Jan 29;12(2):311.|Gastroenterology. 2024 Jan 24:S0016-5085(24)00064-7.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-15858/AP-III-a4-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-15858/AP-III-a4-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1177827-73-4
Available Sizes
Curated Selection
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