Anti-DNAJC3 Antibody Picoband® Fluoro488 Conjugated

DnaJ homolog subfamily C member 3 is a protein that in humans is encoded by the DNAJC3 gene. This gene encodes a protein with multiple tetratricopeptide repeat (TPR) motifs as well as the highly conserved J domain found in DNAJ chaperone family members. It is a member of the tetratricopeptide repeat family of proteins and acts as an inhibitor of the interferon-induced, dsRNA-activated protein kinase (PKR) .

Mediator of RNA polymerase II transcription subunit 14; Activator-recruited cofactor 150 kDa component; ARC150; Cofactor required for Sp1 transcriptional activation subunit 2; CRSP complex subunit 2; Mediator complex subunit 14; RGR1 homolog; hRGR1; Thyroid hormone receptor-associated protein complex 170 kDa component; Trap170; Transcriptional coactivator CRSP150; Vitamin D3 receptor-interacting protein complex 150 kDa component; DRIP150; MED14; ARC150, CRSP2, CXorf4, DRIP150, EXLM1, RGR1, TRAP170

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

1. Barber, G. N., Wambach, M., Thompson, S., Jagus, R., Katze, M. G. Mutants of the RNA-dependent protein kinase (PKR) lacking double-stranded RNA binding domain I can act as transdominant inhibitors and induce malignant transformation. Molec. Cell. Biol. 15: 3138-3146, 1995. 2. Bublitz, S. K., Alhaddad, B., Synofzik, M., Kuhl, V., Lindner, A., Freiberg, C., Schmidt, H., Strom, T. M., Haack, T. B., Deschauer, M. Expanding the phenotype of DNAJC3 mutations: a case with hypothyroidism additionally to diabetes mellitus and multisystemic neurodegeneration. (Letter) Clin. Genet. 92: 561-562, 2017. 3. Gale, M., Jr., Blakely, C. M., Hopkins, D. A., Melville, M. W., Wambach, M., Romano, P. R., Katze, M. G. Regulation of interferon-induced protein kinase PKR: modulation of P58 (IPK) inhibitory function by a novel protein, P52 (rIPK) . Molec. Cell. Biol. 18: 859-871, 1998.