Streptolysin O (≥1000000 units/mg)

Streptolysin O (≥1000000 units/mg) is a ≥1000000 units/mg Streptolysin O (HY-135416) . Streptolysin O, a group A streptococcal toxin, is a well-characterized oxygen-labile prototype of a cholesterol-binding bacterial exotoxin. Streptolysin O causes both lysis of cells and cardiotoxicity. Streptolysin O is widely used for the controlled permeabilization of cell membranes. Streptolysin O exists in two forms, a reduced active state and an oxidized reversibly inactive state[1][2][3][4].

Product Specifications

CAS Number

[98072-47-0]

UNSPSC

12352100

Hazard Statement

H300+H310+H330, H315, H318, H411

Target

Endogenous Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/streptolysin-o-1000000-units-mg.html

Purity

96.0

Solubility

10 mM in DMSO

Smiles

[StreptolysinO(?000000units/mg)]

Precautions

H300+H310+H330, H315, H318, H411

References & Citations

[1]Sierig G, et al. Cytotoxic effects of streptolysin o and streptolysin s enhance the virulence of poorlyencapsulated group a streptococci. Infect Immun. 2003 Jan;71 (1) :446-55.|[2]Van Epps DE, et al. Streptolysin O II. Relationship of Sulfyhdryl Groups to Activity. Infect Immun. 1971 May;3 (5) :648-52.|[3]Uchiyama S, et al. Streptolysin O Rapidly Impairs Neutrophil Oxidative Burst and Antibacterial Responses to Group A Streptococcus. Front Immunol. 2015 Nov 16;6:581.|[4]Yamamoto I, et al. Mutational and comparative analysis of streptolysin O, an oxygen-labile streptococcal hemolysin. Biosci Biotechnol Biochem. 2001 Dec;65 (12) :2682-9.