BT317
Product Specifications
UNSPSC Description
BT317 is a blood-brain transmissible mitochondrial Lon peptidase I (LonP1) and CT-L proteasome inhibitor. BT317 can increase the production of reactive oxygen species (ROS) and induce apoptosis in astrocytoma cells. BT317 has antitumor activity[1].
Target Antigen
Apoptosis; Proteasome
Type
Reference compound
Related Pathways
Apoptosis;Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bt317.html
Solubility
DMF : 2 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
COC1=CC=C(C=C1)NC(C2=CC3=CC(Cl)=CC=C3OC2=O)=O
Molecular Weight
329.73
References & Citations
[1]Douglas C, et al. Dual targeting of mitochondrial Lon peptidase 1 and chymotrypsin-like protease by small molecule BT317, as potential therapeutics in malignant astrocytoma. bioRxiv, 2023: 2023.04. 13.536816.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-158412/BT317-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-158412/BT317-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
38485-94-8
Available Sizes
Curated Selection
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