Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-5HT1B/HTR1B Antibody Picoband® Fluoro647 Conjugated

Selected Variant

A01826-2-Fluoro647

Size: 100 µg/Vial

Product Specifications

Background

5-hydroxytryptamine receptor 1B also known as the 5-HT1B receptor is a protein that in humans is encoded by the HTR1B gene. The protein encoded by this intronless gene is a G-protein coupled receptor for serotonin (5-hydroxytryptamine) . Ligand binding activates second messengers that inhibit the activity of adenylate cyclase and manage the release of serotonin, dopamine, and acetylcholine in the brain. The encoded protein may be involved in several neuropsychiatric disorders and therefore is often a target of antidepressant and other psychotherapeutic drugs.

Synonyms

Thy-1 membrane glycoprotein; CDw90; Thy-1 antigen; CD90; THY1

Gene Name

HTR1B

Gene ID

3351

UniProt

P28222

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human 5HT1B/HTR1B recombinant protein (Position: A35-S390) .

Clonality

Polyclonal

Tissue Specificity

Detected adjacent to nodes of Ranvier in juxtaparanodal zones in spinal cord nerve fibers, but also in paranodal regions in some myelinated spinal cord axons (at protein level) (PubMed:11086297) . Detected in the islet of Langerhans (PubMed:21483673) .

Applications

Flow Cytometry

Field of Research

Neuroscience, Stem Cells, Synapse Marker, T Cells, T Lymphocytic Lineage

Purification

Immunogen affinity purified.

Form

Liquid

Function

May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.

References & Citations

1. Bartsch, T., Knight, Y. E., Goadsby, P. J. Activation of 5-HT (1B/1D) receptor in the periaqueductal gray inhibits nociception. Ann. Neurol. 56: 371-381, 2004. 2. Demchyshyn, L., Sunahara, R. K., Miller, K., Teitler, M., Hoffman, B. J., Kennedy, J. L., Seeman, P., Van Tol, H. H. M., Niznik, H. B. A human serotonin 1D receptor variant (5HT1D-beta) encoded by an intronless gene on chromosome 6. Proc. Nat. Acad. Sci. 89: 5522-5526, 1992. 3. Garcia-Nafria, J., Nehme, R., Edwards, P. C., Tate, C. G. Cryo-EM structure of the serotonin 5-HT (1B) receptor coupled to heterotrimeric G (o) . Nature 558: 620-623, 2018.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

18080 MW

Applications Notes

6

Gene Name Synonym

Thy-1 cell surface antigen

Subcellular Location

Cell membrane; Lipid-anchor, GPI-anchor.

Protein Name

Thy-1 membrane glycoprotein

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Price

Sign In for Pricing

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

CD68 (C68/684), CF647 conjugate, 0.1mg/mL
BNC470684-100 1x 100 µL

CD68 (C68/684), CF647 conjugate, 0.1mg/mL

Sign In for Pricing
View Details
Anti-Toll-like receptor 4 TLR4 Antibody Picoband®, PE Conjugate
PA1484-PE 100 µg/Vial

Anti-Toll-like receptor 4 TLR4 Antibody Picoband®, PE Conjugate

Sign In for Pricing
View Details
Human CA9 PicoKine® Quick ELISA Kit
FEK0682 96 Well With Removable Strips

Human CA9 PicoKine® Quick ELISA Kit

Sign In for Pricing
View Details
PD1, Mouse (RMP1-14), CF647 conjugate, 0.1mg/mL
BNC472002-500 1x 500 µL

PD1, Mouse (RMP1-14), CF647 conjugate, 0.1mg/mL

Sign In for Pricing
View Details
Anti-NCS1 Rabbit Monoclonal Antibody
M05330 100 µL/Vial

Anti-NCS1 Rabbit Monoclonal Antibody

Sign In for Pricing
View Details
Insulin (2D11-H5), CF568 conjugate, 0.1mg/mL
BNC680030-500 1x 500 µL

Insulin (2D11-H5), CF568 conjugate, 0.1mg/mL

Sign In for Pricing
View Details