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Anti-SLC22A3 Antibody Picoband® Fluoro594 Conjugated

Product Specifications

Background

Solute carrier family 22 (extraneuronal monoamine transporter), member 3, also known as SLC22A3 or OCT3 is a protein that in humans is encoded by the SLC22A3 gene. This gene is mapped to 6q25.3. Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene mediates potential-dependent transport of a variety of organic cations. It may play a significant role in the disposition of cationic neurotoxins and neurotransmitters in the brain.

Synonyms

Smoothelin; SMTN; SMSMO

Gene Name

SLC22A3

Gene ID

6581

UniProt

O75751

Host

Rabbit

Reactivity

Human, Mouse

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human SLC22A3, which shares 76.5% amino acid (aa) sequence identity with both mouse and rat SLC22A3.

Clonality

Polyclonal

Tissue Specificity

Smooth muscle; contractile or vascular (for the long form) .

Applications

Flow Cytometry

Field of Research

Vasculature

Purification

Immunogen affinity purified.

Form

Liquid

Function

Structural protein of the cytoskeleton.

References & Citations

1. Lazar, A., Grundemann, D., Berkels, R., Taubert, D., Zimmermann, T., Schomig, E. Genetic variability of the extraneuronal monoamine transporter EMT (SLC22A3) . J. Hum. Genet. 48: 226-230, 2003. 2. Nagano, T., Mitchell, J. A., Sanz, L. A., Pauler, F. M., Ferguson-Smith, A. C., Feil, R., Fraser, P. The Air noncoding RNA epigenetically silences transcription by targeting G9a to chromatin. Science 322: 1717-1720, 2008. 3. Sleutels, F., Zwart, R., Barlow, D. P. The non-coding Air RNA is required for silencing autosomal imprinted genes. Nature 415: 810-813, 2002.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

56903 MW

Applications Notes

6

Gene Name Synonym

Smoothelin

Subcellular Location

Cytoplasm, cytoskeleton. Exhibits a filamentous organization.

Protein Name

Vesicular acetylcholine transporter

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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