What sizes are available for Anti-Kallistatin/PI-4/SERPINA4 Antibody Picoband® Fluoro647 Conjugated?

Anti-Kallistatin/PI-4/SERPINA4 Antibody Picoband® Fluoro647 Conjugated is available in the following size(s): 100 µg/Vial.

Do you offer custom or private-label production of this type of product?

Yes, custom antibody development and private-label production services are available. Contact our sales team to discuss your target, timeline, and quantity requirements.

What is the immunogen used to generate this antibody?

Immunogen or antigen details used to raise this antibody are listed on the product datasheet under immunogen information.

What is the recommended positive control for this assay?

A recommended positive control, where one is specified by the manufacturer, is listed on the datasheet or in the assay protocol.

Anti-Kallistatin/PI-4/SERPINA4 Antibody Picoband® Fluoro647 Conjugated

Q: What is the catalog number for Anti-Kallistatin/PI-4/SERPINA4 Antibody Picoband® Fluoro647 Conjugated?

The catalog number for Anti-Kallistatin/PI-4/SERPINA4 Antibody Picoband® Fluoro647 Conjugated is A08426-Fluoro647.

Selected Variant

A08426-Fluoro647

Size: 100 µg/Vial

Product Specifications

Background

Kallistatin is a protein that in humans is encoded by the SERPINA4 gene. It is mapped to 14q32.13. Serpin A4 is a member of the Serpin superfamily of the serine protease inhibitors. Known also as Kallistatin or proteinase inhibitor 4, Serpin A4 has been shown to function as a specific inhibitor of tissue kallikrein and as an inhibitor of angiogenesis and tumor growth.

Synonyms

Kallistatin; Kallikrein inhibitor; Peptidase inhibitor 4; PI-4; Serpin A4; SERPINA4; KST; PI4

Gene Name

SERPINA4

Gene ID

5267

UniProt

P29622

Host

Rabbit

Reactivity

Human, Monkey, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human Kallistatin/PI-4/SERPINA4 recombinant protein (Position: H147-A373) .

Clonality

Polyclonal

Tissue Specificity

Expressed by the liver and secreted in plasma.

Applications

Flow Cytometry

Field of Research

Cancer, Cell Biology, Cytoskeleton/ECM, ECM Enzymes, Extracellular Matrix, Invasion/Microenvironment, Metalloprotease, Proteolysis/Ubiquitin, Proteolytic Enzymes, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

Inhibits human amidolytic and kininogenase activities of tissue kallikrein. Inhibition is achieved by formation of an equimolar, heat- and SDS-stable complex between the inhibitor and the enzyme, and generation of a small C-terminal fragment of the inhibitor due to cleavage at the reactive site by tissue kallikrein.

References & Citations

1. Chai, K. X., Chen, L.-M., Chao, J., Chao, L. Kallistatin: a novel human serine proteinase inhibitor: molecular cloning, tissue distribution, and expression in Escherichia coli. J. Biol. Chem. 268: 24498-24505, 1993. 2. Chai, K. X., Ward, D. C., Chao, J., Chao, L. Molecular cloning, sequence analysis, and chromosomal localization of the human protease inhibitor 4 (kallistatin) gene (PI4) . Genomics 23: 370-378, 1994. 3. Miao, R. Q., Agata, J., Chao, L., Chao, J. Kallistatin is a new inhibitor of angiogenesis and tumor growth. Blood 100: 3245-3252, 2002.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

82457 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

Gene Name Synonym

Serpin family A member 4

Subcellular Location

Secreted.

Protein Name

Disintegrin and metalloproteinase domain-containing protein 2

Isotype

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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