Anti-MESP1 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Mesoderm posterior 1 homolog (mouse) is a protein that in humans is encoded by the MESP1 gene. It is mapped to 15q26.1. MESP1 is a transcription factor that regulates cardiovascular progenitor specification.The MESP1 gene encodes a member of the basic helix-loop-helix (bHLH) family of transcriptional regulatory proteins that may play a role in the development of nascent mesoderm.
Synonyms
Mesoderm posterior protein 1; Class C basic helix-loop-helix protein 5; bHLHc5; MESP1; BHLHC5
Gene Name
MESP1
Gene ID
55897
UniProt
Q9BRJ9
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human MESP1 recombinant protein (Position: M1-K268) .
Clonality
Polyclonal
Tissue Specificity
Highly expressed in brain and weakly in heart, small intestine and uterus. Isoform 1A is mostly expressed in granular cell and molecular layer. Isoform 1B is mostly expressed in Purkinje cells. Isoform 1E is predominantly expressed in peripheral tissues as kidney, lung, trachea, colon, small intestine, stomach, bone marrow, thymus and mammary gland. .
Applications
Flow Cytometry
Field of Research
Interleukins
Purification
Immunogen affinity purified.
Form
Liquid
Function
Transcription factor. Plays a role in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm. Defines the rostrocaudal patterning of the somites by participating in distinct Notch pathways.
References & Citations
1. Lescroart, F., Wang, X., Lin, X., Swedlund, B., Gargouri, S., Sanchez-Danes, A., Moignard, V., Dubois, C., Paulissen, C., Kinston, S., Gottgens, B., Blanpain, C. Defining the earliest step of cardiovascular lineage segregation by single-cell RNA-seq. Science 359: 1177-181, 2018. 2. Saga, Y., Hata, N., Kobayashi, S., Magnuson, T., Seldin, M. F., Taketo, M. M. MesP1: a novel basic helix-loop-helix protein expressed in the nascent mesodermal cells during mouse gastrulation. Development 122: 2769-2778, 1996. 3. Whittock, N. V., Sparrow, D. B., Wouters, M. A., Sillence, D., Ellard, S., Dunwoodie, S. L., Turnpenny, P. D. Mutated MESP2 causes spondylocostal dysostosis in humans. Am. J. Hum. Genet. 74: 1249-1254, 2004.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
108320 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Mesoderm posterior bHLH transcription factor 1
Subcellular Location
Nucleus.
Protein Name
Gamma-aminobutyric acid type B receptor subunit 1
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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