Anti-TNFRSF14 Antibody

Herpesvirus entry mediator (HVEM), also known as tumor necrosis factor receptor superfamily member 14 (TNFRSF14), is a human cell surface receptor of the TNF-receptor superfamily. The encoded protein functions in signal transduction pathways that activate inflammatory and inhibitory T-cell immune response. It binds herpes simplex virus (HSV) viral envelope glycoprotein D (gD), mediating its entry into cells. Alternative splicing results in multiple transcript variants.

Tumor necrosis factor receptor superfamily member 14; Herpes virus entry mediator A; Herpesvirus entry mediator A; HveA; Tumor necrosis factor receptor-like 2; TR2; CD270; TNFRSF14; HVEA, HVEM; UNQ329/PRO509

Antiviral Signaling, Cancer, Cytokines, Growth Factors, Growth Factors/Hormones, Immune System Diseases, Immunology, Innate Immunity, Signal Transduction, TNF Superfamily

Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells. .

1. Kwon BS, Tan KB, Ni J, Oh KO, Lee ZH, Kim KK, Kim YJ, Wang S, Gentz R, Yu GL, Harrop J, Lyn SD, Silverman C, Porter TG, Truneh A, Young PR (June 1997) . A newly identified member of the tumor necrosis factor receptor superfamily with a wide tissue distribution and involvement in lymphocyte activation. J Biol Chem 272 (22) : 14272–6. 2. Montgomery RI, Warner MS, Lum BJ, Spear PG (Dec 1996) . Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family. Cell 87 (3) : 427–36. 3. Ware, Carl (2008) . Chapter 25: TNF-Related Cytokines in Immunity. In Paul, William. Fundamental Immunology (Book) (6th ed.) . Philadelphia: Lippincott Williams & Wilkins. pp. 776–801. 4. Schmidt-Ott KM, Mori K, Li JY, Kalandadze A, Cohen DJ, Devarajan P, Barasch J (February 2007) . Dual action of neutrophil gelatinase-associated lipocalin. J. Am. Soc. Nephrol. 18 (2) : 407–13.

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.