What sizes are available for Anti-GAS 6/GAS6 Antibody Picoband® Fluoro647 Conjugated?

Anti-GAS 6/GAS6 Antibody Picoband® Fluoro647 Conjugated is available in the following size(s): 100 µg/Vial.

What buffer is this product supplied in?

The formulation or storage buffer is listed on the product datasheet. If you require a carrier-free or custom formulation, contact us before ordering, as this may involve a made-to-order production timeline.

What dilution range is recommended for immunohistochemistry (IHC) with this antibody?

A starting IHC dilution range is listed on the datasheet, but should be optimized for your specific tissue type and staining protocol.

Can I request a Safety Data Sheet (SDS) for this product?

Yes, safety data sheets are available for hazardous or chemically classified products and can be provided on request or downloaded from the product page.

Anti-GAS 6/GAS6 Antibody Picoband® Fluoro647 Conjugated

Q: What is the catalog number for Anti-GAS 6/GAS6 Antibody Picoband® Fluoro647 Conjugated?

The catalog number for Anti-GAS 6/GAS6 Antibody Picoband® Fluoro647 Conjugated is A00608-1-Fluoro647.

Q: Is Anti-GAS 6/GAS6 Antibody Picoband® Fluoro647 Conjugated in stock?

Anti-GAS 6/GAS6 Antibody Picoband® Fluoro647 Conjugated is currently made to order / not held in immediate stock. Contact us for lead time.

Selected Variant

A00608-1-Fluoro647

Size: 100 µg/Vial

Product Specifications

Background

Growth arrest-specific 6, also known as GAS6, is a human gene coding for the Gas6 protein. It is similar to the Protein S with the same domain organization and 43% amino acid identity. It was originally found as a gene upregulated by growth arrested fibroblasts. This gene is frequently overexpressed in many cancers and has been implicated as an adverse prognostic marker. Elevated protein levels are additionally associated with a variety of disease states, including venous thromboembolic disease, systemic lupus erythematosus, chronic renal failure, and preeclampsia.

Synonyms

Growth arrest-specific protein 6; GAS-6; AXL receptor tyrosine kinase ligand; GAS6; AXLLG

Gene Name

GAS6

Gene ID

2621

UniProt

Q14393

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human GAS 6 recombinant protein (Position: M488-S660) . Human GAS 6 shares 79.7% and 81.4% amino acid (aa) sequence identity with mouse and rat GAS 6, respectively.

Clonality

Polyclonal

Tissue Specificity

Plasma. Isoform 1 and isoform 2 are widely expressed. Isoform 1 is the predominant form in spleen. .

Applications

Flow Cytometry

Field of Research

Atherosclerosis, Cardiovascular, Hematopoietic Progenitors, Mesenchymal Stem Cells, Myeloid, Protein Phosphorylation, Receptor Tyrosine Kinases, Signal Transduction, Stem Cells, Tyrosine Kinases

Purification

Immunogen affinity purified.

Form

Liquid

Function

Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. .

References & Citations

1. Mark MR, Chen J, Hammonds RG, Sadick M, Godowsk PJ (Apr 1996) . Characterization of Gas6, a member of the superfamily of G domain-containing proteins, as a ligand for Rse and Axl. J. Biol. Chem. 271 (16) : 9785–9. 2. Nagata K, Ohashi K, Nakano T, Arita H, Zong C, Hanafusa H, Mizuno K (Nov 1996) . Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases. J. Biol. Chem. 271 (47) : 30022–7.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

79 kDa

Specificity

No cross reactivity with other proteins.

Applications Notes

Gene Name Synonym

Growth arrest-specific protein 6

Subcellular Location

Secreted .

Protein Name

Growth arrest-specific protein 6

Isotype

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Price

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