PD1 / PDCD1 / CD279 (PDCD1/922), CF555 conjugate, 0.1mg/mL
PD-1 (also known as Programmed Death 1, CD279, and PDCD1) is a negative regulatory T cell surface receptor. PD-1 is a Type I transmembrane protein expressed on the plasma membrane of T-cells. It is a T-cell checkpoint protein, involved in preventing autoimmunity. Because binding of PD-1 by its ligands PD-L1 or PD-L2 has a suppressive effect on the immune system, inhibition of the PD-1/PD-L1 pathway is a major strategy of immune-oncology therapies. PD-L1 is upregulated in certain cancers, and blocking PD-1 or PD-L1 can inhibit cancer growth. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
Product Specifications
Synonyms
CD279; hPD-1; hSLE1; PD1; PDCD1; Programmed Cell Death Protein 1; Protein PD-1; SLEB2; Systemic lupus erythematosus susceptibility 2
UNSPSC
41116161
UNSPSC Description
Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name
PDCD1
Gene ID
5133
NCBI Gene ID
158297
UniProt
Q15116
Swiss Prot
Q15116
Host
Mouse
Species Reactivity
Human
Reactivity
CD279|PD1|PDCD1
Immunogen
Recombinant full-length human PDCD1 protein
Target Antigen
CD279 | PD1 | PDCD1
Clonality
Monoclonal
Clone
PDCD1/922
Type
Primary
Source
Animal
Origin
Animal
Applications
Flow (verified) |IF (verified) |IHC, FFPE (verified)
Field of Research
Apoptosis, Cancer, Cancer immunotherapy/immune checkpoint
Positive Control
TY cells or Tonsil.
Stability
2 years
Concentration
0.1 mg/mL
Buffer
PBS, 0.1% BSA, 0.05% azide
Molecular Weight
55 kDa
Shipping Conditions
RT (ND)
Storage Conditions
Stable at room temperature or 37°C (98°F) for 7 days.
Notes
Protect from light
Shelf Life
Guaranteed for at least 24 months from date of receipt when stored as recommended
Product Datasheet
https://cdn.gentaur.com/products/37/889901/datasheet/bnc550922-500.pdf
Product MSDS
https://cdn.gentaur.com/products/37/68dd02b4061270361e10acb3/msds/bnc550922-500.pdf
Fragment
IgG1, kappa
Species
Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification
0.05% sodium azide (CAS 26628-22-8)
CAS Number
9007-83-4
Conjugate
CF555
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