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Anti-FDCSP Antibody

Boster Bio Anti-FDCSP Antibody Picoband® catalog # A13093-1. Tested in IHC, IF applications. This antibody reacts with Human.

Product Specifications

Background

FDC-SP or follicular dendritic cell-secreted protein, is a small, secreted protein, located on chromosome 4 in humans. FDC-SP is a 68-amino acid protein containing a signal peptide at its N terminus, which is used for ing the transport of the protein. This protein specifically binds to activated B cells, and functions as a regulator of antibody responses. It is also thought to contribute to tumor metastases by promoting cancer cell migration and invasion.

Synonyms

Follicular dendritic cell secreted peptide; FDC secreted protein; FDC-SP; FDCSP; C4orf7; UNQ733/PRO1419

Gene Name

FDCSP

Gene ID

260436

UniProt

Q8NFU4

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human FDCSP.

Clonality

Polyclonal

Tissue Specificity

Abundantly expressed in tonsil, lymph node, and trachea; strong expression in prostate; lower expression in thyroid, stomach, and colon. .

Applications

IF, IHC

Field of Research

Immunology, Secreted Molecules

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Can bind to the surface of B-lymphoma cells, but not T- lymphoma cells, consistent with a function as a secreted mediator acting upon B-cells.

References & Citations

1. Aaron J. Marshall; et al. (September 1, 2002) . FDC-SP, a Novel Secreted Protein Expressed by Follicular Dendritic Cells. The Journal of Immunology. 169 (5) : 2381–2389. 2. Tamayuki Shinomura; et al. (November 28, 2008) . Adsorption of Follicular Dendritic Cell-secreted Protein (FDC-SP) onto Mineral Deposits. J. Biol. Chem. 283 (48) : 33658–33664.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

9700 MW

Observed Molecular Weight

28 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Follicular dendritic cell secreted peptide

Subcellular Location

Secreted.

Protein Name

Follicular dendritic cell secreted peptide

Isotype

Rabbit IgG

Contents

Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

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