Flindersine

Flindersine is an antidiabetic and antioxidant agent. Flindersine can result in a decline of blood glucose levels in rats. Flindersine also reduces the body weight gain, plasma insulin concentration, urea, creatinine, total cholesterol, triglycerides and free fatty acids levels in vivo. Flindersine enhances the phophotylation of GLUT4, AMPK, and PPARγ in adipose tissues and skeletal muscles[1].

Product Specifications

CAS Number

[523-64-8]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

AMPK; GLUT; PPAR; Reactive Oxygen Species (ROS)

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Smiles

O=C1NC2=C(C3=C1C=CC(C)(C)O3)C=CC=C2

Molecular Formula

C14H13NO2

Molecular Weight

227.26

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Irudayaraj, S. S., et al., (2022) . Antidiabetic with antilipidemic and antioxidant effects of flindersine by enhanced glucose uptake through GLUT4 translocation and PPARγ agonism in type 2 diabetic rats. Journal of ethnopharmacology, 285, 114883.