Anti-Carboxypeptidase B2/CPB2 Antibody Picoband® Fluoro594 Conjugated
Product Specifications
Background
Carboxypeptidase B2 (CPB2), also known as carboxypeptidase U (CPU), plasma carboxypeptidase B (pCPB) or thrombin-activatable fibrinolysis inhibitor (TAFI), is an enzyme that, in humans, is encoded by the gene CPB2. CPB2 is synthesized by the liver and circulates in the plasma as a plasminogen-bound zymogen. When it is activated by proteolysis at residue Arg92 by the thrombin/thrombomodulin complex, CPB2 exhibits carboxypeptidase activity. Activated CPB2 reduces fibrinolysis by removing the fibrin C-terminal residues that are important for the binding and activation of plasminogen.
Synonyms
Carboxypeptidase B2;3.4.17.20; Carboxypeptidase R; CPR; Carboxypeptidase U; CPU; Thrombin-activable fibrinolysis inhibitor; TAFI; Cpb2; Tafi
Gene Name
Cpb2
Gene ID
56373
UniProt
Q9JHH6
Host
Rabbit
Reactivity
Mouse
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
E. coli-derived mouse CPB2 recombinant protein (Position: K165-D387) . Mouse CPB2 shares 86.1% and 96.9% amino acid (aa) sequence identity with human and rat CPB2, respectively.
Clonality
Polyclonal
Tissue Specificity
Plasma; synthesized in the liver. .
Applications
Flow Cytometry
Field of Research
Cardiovascular, Heart Disease, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Serum Proteins, Signal Transduction
Purification
Immunogen affinity purified.
Form
Liquid
Function
Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down- regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin.
References & Citations
1. Boffa MB, Reid TS, Joo E, Nesheim ME, Koschinsky ML (May 1999) . Characterization of the gene encoding human TAFI (thrombin-activable fibrinolysis inhibitor; plasma procarboxypeptidase B) . Biochemistry 38 (20) : 6547–58. 2. Eaton DL, Malloy BE, Tsai SP, Henzel W, Drayna D (Dec 1991) . Isolation, molecular cloning, and partial characterization of a novel carboxypeptidase B from human plasma. J Biol Chem 266 (32) : 21833–8. 3. Tsai SP, Drayna D (Dec 1992) . The gene encoding human plasma carboxypeptidase B (CPB2) resides on chromosome 13. Genomics14 (2) : 549–50.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
48871 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Carboxypeptidase B2
Subcellular Location
Secreted .
Protein Name
Carboxypeptidase B2
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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