Anti-MUC3/MUC3A/MUC3B Antibody Picoband®

Boster Bio Anti-MUC3/MUC3A/MUC3B Antibody Picoband® catalog # PB9955. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

MUC3 consists of two genes, MUC3A and MUC3B, each encoding membrane-bound mucins possessing 2 epidermal growth factor-like domains. The MUC3 gene is mapped to chromosome 7. It was showed that synthetic peptide-mediated upregulation of MUC3 dramatically inhibited adherence of enteropathogenic E. coli or enterohemorrhage E. coli serotype O157:H7 to HT-29 human intestinal epithelial cells. Peptide stimulation altered expression of a number of transcription factors, including upregulation of SP1, CREB1, and CDX2. These transcription factors bound to consensus sites in the MUC3 promoter upon peptide stimulation and likely mediated MUC3 upregulation.

Synonyms

Mucin-3B ; MUC-3B ; Intestinal mucin-3B ; MUC3B

Gene Name

MUC3B

Gene ID

4584/57876

UniProt

Q9H195

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human MUC3.

Clonality

Polyclonal

Tissue Specificity

Fetal and adult small intestine and fetal and adult colon. .

Applications

Field of Research

Cytoskeleton/ECM, ECM Proteins, Extracellular Matrix, Signal Transduction

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Major glycoprotein component of a variety of mucus gels. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces (By similarity) . .

References & Citations

1. Fox, M., Lahbib, F., Pratt, W., Attwood, J., Gum, J., Kim, Y., Swallow, D. M. Regional localisation of MUC3 to chromosome 7q22. (Abstract) Cytogenet. Cell Genet. 58: 1920-1921, 1991. 2. Pan, Q., Tian, Y., Li, X., Ye, J., Liu, Y., Song, L., Yang, Y., Zhu, R., He, Y., Chen, L., Chen, W., Mao, X., Peng, Z., Wang, R. Enhanced membrane-tethered mucin 3 (MUC3) expression by a tetrameric branched peptide with a conserved TFLK motif inhibits bacteria adherence. J. Biol. Chem. 288: 5407-5416, 2013. 3. Williams, S. J., Munster, D. J., Quin, R. J., Gotley, D. C., McGuckin, M. A. The MUC3 gene encodes a transmembrane mucin and is alternatively spliced. Biochem. Biophys. Res. Commun. 261: 83-89, 1999.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

131402 MW

Observed Molecular Weight

345 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Mucin-3B

Subcellular Location

Membrane ; Single-pass membrane protein .

Protein Name

Mucin-3A/Mucin-3B

Isotype

Rabbit IgG

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

More Discoveries

Explore Other Products

Browse additional items from our catalog

215911 500 µg

Bacillus anthracis, Protective Antigen, Recombinant (Anthrax)

View Details

K4015202 1.0 µg DNA

1810030J14Rik sgRNA CRISPR Lentivector (Mouse) (Target 1)

View Details

AP15137PU-N 400 µL

PFKFB3 (C-term) Rabbit Polyclonal Antibody

View Details

K7464402 1.0 µg DNA

Olr360 sgRNA CRISPR Lentivector (Rat) (Target 1)

View Details

A20026-100 100 mg

NITD-349 100mg

View Details

MR209190L3V 200 µL

Grk6 (NM_001112711) Mouse Tagged ORF Clone Lentiviral Particle

View Details

Anti-MUC3/MUC3A/MUC3B Antibody Picoband®

Product Specifications

Background

Synonyms

Gene Name

Gene ID

UniProt

Host

Reactivity

Cross Reactivity

Immunogen

Clonality

Tissue Specificity

Applications

Field of Research

Purification

Concentration

Form

Reconstitution

Function

References & Citations

Storage Conditions

Calculated Molecular Weight

Observed Molecular Weight

Specificity

Gene Name Synonym

Subcellular Location

Protein Name

Isotype

Contents

Explore Other Products

Bacillus anthracis, Protective Antigen, Recombinant (Anthrax)

1810030J14Rik sgRNA CRISPR Lentivector (Mouse) (Target 1)

PFKFB3 (C-term) Rabbit Polyclonal Antibody

Olr360 sgRNA CRISPR Lentivector (Rat) (Target 1)

NITD-349 100mg

Grk6 (NM_001112711) Mouse Tagged ORF Clone Lentiviral Particle