Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-MGP Antibody Picoband®

Boster Bio Anti-MGP Antibody Picoband® catalog # PB9954. Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

Matrix Gla protein (MGP) is an 84-residue vitamin K-dependent protein initially isolated from bovine bone. In addition, MGP is a 10-kD protein produced and secreted by vascular smooth muscle cells and chondrocytes and significantly accumulated in bone, cartilage, and dentin. It is also expressed at high levels in heart, kidney, and lung and is upregulated by vitamin D in bone cells. MGP has a high affinity binding to calcium ions, similar to other Gla-containing proteins. The protein acts as an inhibitor of vascular mineralization and plays a role in bone organization. And this gene is mapped to 12p12.3.

Synonyms

Matrix Gla protein; MGP; Cell growth-inhibiting gene 36 protein; MGP; MGLAP; GIG36

Gene Name

MGP

Gene ID

4256

UniProt

P08493

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human MGP recombinant protein (Position: Y20-F96) . Human MGP shares 84.4% and 80.5% amino acid (aa) sequence identity with mouse and rat MGP, respectively.

Clonality

Polyclonal

Tissue Specificity

Isoform MEF2 and isoform MEFA are expressed only in skeletal and cardiac muscle and in the brain. Isoform RSRFC4 and isoform RSRFC9 are expressed in all tissues examined. .

Applications

IHC, WB

Field of Research

Cytoskeleton/ECM, ECM Proteins, Extracellular Matrix, Signal Transduction, Structures

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.

References & Citations

1. Hur, D. J., Raymond, G. V., Kahler, S. G., Riegert-Johnson, D. L., Cohen, B. A., Boyadjiev, S. A. A novel MGP mutation in a consanguineous family: review of the clinical and molecular characteristics of Keutel syndrome. Am. J. Med. Genet. 135A: 36-40, 2005. 2. Luo G, Ducy P, McKee MD, Pinero GJ, Loyer E, Behringer RR, Karsenty G (March 1997) . Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein. Nature 386 (6620) : 78–81. 3. Yao Y, Jumabay M, Ly A, Radparvar M, Cubberly MR, Boström KI (2013) . A role for the endothelium in vascular calcification. Circ. Res. 113 (5) : 495–504.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

12353 MW

Observed Molecular Weight

12 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Matrix Gla protein

Subcellular Location

Secreted.

Protein Name

Matrix Gla protein

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

MRPL45 (NM_032351) Human Tagged Lenti ORF Clone
RC218954L4 10 µg

MRPL45 (NM_032351) Human Tagged Lenti ORF Clone

Ask
View Details
NRL CytoSection
TS402237P5 25 Slides

NRL CytoSection

Ask
View Details
Mouse HDX shRNA Plasmid
abx982765-01 150 µg

Mouse HDX shRNA Plasmid

Ask
View Details
Mouse HDX shRNA Plasmid
abx982765-02 300 µg

Mouse HDX shRNA Plasmid

Ask
View Details
Frozen Tissue Sections, Kidney
CS618761 5x 5 µm

Frozen Tissue Sections, Kidney

Ask
View Details
Axitinib Nitroso Impurity 72
RM-A164872-01 10 mg

Axitinib Nitroso Impurity 72

Ask
View Details