Anti-ELAVL4 Antibody Picoband® Fluoro488 Conjugated

HuD?otherwise known as?ELAV-like protein 4 or PNEM?is a?protein?that in humans is encoded by the?ELAVL4?gene. This human gene is located at 1p34 by in situ hybridization. The HuD/ELAVL4 protein is an?RNA-binding protein. ELAVL4?has specificity for 3-prime uridylate-rich untranslated regions of growth factor mRNAs. And HuD is expressed only in neurons and it binds to?AU-rich element-containing mRNAs. As a result of this interaction the, half-life of the transcript is increased. Also, HuD is important in neurons during brain development and plasticity.

A synthetic peptide corresponding to a sequence at the N-terminus of human ELAVL4, different from the related mouse and rat sequences by one amino acid.

Cell Type Marker, DNA/RNA, Epigenetics and Nuclear Signaling, Intracellular, Neural Stem Cells, Neuron Marker, Neuroscience, RNA Processing, Stem Cells

May play a role in neuron-specific RNA processing. Protects CDKN1A mRNA from decay by binding to its 3'-UTR (By similarity) . Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF and FOS mRNA. .

1. Entrez Gene: ELAVL4 ELAV (embryonic lethal, abnormal vision, Drosophila) -like 4 (Hu antigen D) . 2. Muresu R, Baldini A, Gress T, Posner JB, Furneaux HM, Siniscalco M (Dec 1993) . Mapping of the gene coding for a paraneoplastic encephalomyelitis antigen (HuD) to human chromosome site 1p34. Cytogenet Cell Genet 65 (3) : 177–8. 3. Nora Perrone-Bizzozero and Federico Bolognani (2002) . Role of HuD and other RNA-binding proteins in neural development and plasticity. J Neurosci Res 68 (2) : 121–126.