Huwentoxin-IV

<strong>Huwentoxin-IV</strong> <strong>Catalog number:</strong> MDP0813 <strong>CAS Number: </strong>2088060-49-3 <strong>Sequence: </strong>Glu-Cys-Leu-Glu-Ile-Phe-Lys-Ala-Cys-Asn-Pro-Ser-Asn-Asp-Gln-Cys-Cys-Lys-Ser-Ser-Lys-Leu-Val-Cys-Ser-Arg-Lys-Thr-Arg-Trp-Cys-Lys-Tyr-Gln-Ile-NH2 (Disulfide bonds between Cys2-Cys17, Cys9-Cys24, and Cys16-Cys31) <strong>Amount:</strong> 100 ug <strong>Molecular Weight:</strong> 4106.8 g/mol <strong>Supplied as:</strong> Powder <strong>Applications:</strong> molecular tool for various biochemical applications <strong>Storage:</strong> -20 °C <strong>WARNING:</strong> For in vitro Research Use Only. NOT for use on humans or animals. <strong>Grade:</strong> Biotechnology grade. All products are highly pure. <strong>References:</strong> 1: Lopez L, Montnach J, Oliveira-Mendes B, Khakh K, Thomas B, Lin S, Caumes C, Wesolowski S, Nicolas S, Servent D, Cohen C, Béroud R, Benoit E, De Waard M. Synthetic Analogues of Huwentoxin-IV Spider Peptide With Altered Human Na(V)1.7/Na(V)1.6 Selectivity Ratios Front Cell Dev Biol. 2021 Dec 20;9:798588. 2: Neff RA, Flinspach M, Gibbs A, Shih AY, Minassian NA, Liu Y, Fellows R, Libiger O, Young S, Pennington MW, Hunter MJ, Wickenden AD. Comprehensive engineering of the tarantula venom peptide huwentoxin-IV to inhibit the human voltage-gated sodium channel hNa(v)1.7 J Biol Chem. 2020 Jan 31;295(5):1315-1327. 3: Xiao Y, Luo X, Kuang F, Deng M, Wang M, Zeng X, Liang S. Synthesis and characterization of huwentoxin-IV, a neurotoxin inhibiting central neuronal sodium channels Toxicon. 2008 Feb;51(2):230-9. 4: Rong M, Duan Z, Chen J, Li J, Xiao Y, Liang S. Native pyroglutamation of huwentoxin-IV: a post-translational modification that increases the trapping ability to the sodium channel PLoS One. 2013 Jun 24;8(6):e65984. 5: Liu Y, Wu Z, Tang D, Xun X, Liu L, Li X, Nie D, Xiang Y, Yi J, Yi J. Analgesic effects of Huwentoxin-IV on animal models of inflammatory and neuropathic pain Protein Pept Lett. 2014;21(2):153-8. 6: Tzakoniati F, Xu H, Li T, Garcia N, Kugel C, Payandeh J, Koth CM, Tate EW. Development of Photocrosslinking Probes Based on Huwentoxin-IV to Map the Site of Interaction on Nav1.7 Cell Chem Biol. 2020 Mar 19;27(3):306-313.e4. 7: Xiao Y, Jackson JO 2nd, Liang S, Cummins TR. Common molecular determinants of tarantula huwentoxin-IV inhibition of Na+ channel voltage sensors in domains II and IV J Biol Chem. 2011 Aug 5;286(31):27301-10. 8: Yu H, Liu H, Yan Y, Duan Z, Wang X. Detection and identification of huwentoxin-IV interacting proteins by biotin-avidin chemistry combined with mass spectrometry J Venom Anim Toxins Incl Trop Dis. 2014 Apr 28;20:18. 9: Xiao Y, Bingham JP, Zhu W, Moczydlowski E, Liang S, Cummins TR. Tarantula huwentoxin-IV inhibits neuronal sodium channels by binding to receptor site 4 and trapping the domain ii voltage sensor in the closed configuration J Biol Chem. 2008 Oct 3;283(40):27300-13. <a href="https://pubmed.ncbi.nlm.nih.gov/28301520">10: Rahnama S, Deuis JR, Cardoso FC, Ramanujam V, Lewis RJ, Rash LD, King GF, Vetter I, Mobli M. The structure, dynamics and selectivity profile of a NaV1.7 potency-optimised huwentoxin-IV variant PLoS One. 2017 Mar 16;12(3):e0173551. </a> <br><strong>Products Related to Huwentoxin-IV can be found at</strong> <a href="https://moleculardepot.com/product-category/Peptides/"> Peptides</a>