1,2,3,4-Tetrahydro Staurosporin
1,2,3,4-Tetrahydrostaurosporine is a derivative of Staurosporine and an inhibitor of mutant EGFR (IC50=74 nM for EGFRT790M). It is selective for EGFRT790M over wild-type EGFR (IC50=390 nM). It also binds to Janus kinase 3 (JAK3).
Product Specifications
CAS Number
220038-19-7
Product Name Alternative
AFN-941
UNSPSC
12352005
Target
EGFR; JAK
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Field of Research
Others
Smiles
C[C@@]12[C@H](OC)[C@H](NC)C[C@@H](O1)N3C4=C(C5=C3C6=C(C7=C5C(NC7)=O)C8=CC=CC=C8N62)CCCC4
Molecular Formula
C28H30N4O3
Molecular Weight
470.56
References & Citations
[1]Song, et al. Staurosporine scaffold-based rational discovery of the wild-type sparing reversible inhibitors of EGFR T790M gatekeeper mutant in lung cancer with analog-sensitive kinase technology. J. Mol. Recognit. 30 (4) :e2590, (2017) .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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