4- (3-Tosyl-2- (tosylmethyl) propanoyl) benzoic acid
4- (3-Tosyl-2- (tosylmethyl) propanoyl) benzoic acid (Bis-sulfone Acid) is a strong covalent linker featuring a free carboxylic acid and two tosyl groups. Each tosyl group can be displaced by thiol or amine nucleophiles via a Michael addition, and the inclusion of two on this molecule allow this reaction to proceed twice. This may be used to “staple” two reduced cysteine residues on a given protein to reform disulfide bridges. The carboxylic acid is free to react to form amides or esters.
Product Specifications
CAS Number
[124243-00-1]
Product Name Alternative
Bis–sulfone Acid
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Biochemical Assay Reagents
Related Pathways
Others
Field of Research
Others
Purity
97.76
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=C(C=C1)C(O)=O)C(CS(=O)(C2=CC=C(C=C2)C)=O)CS(=O)(C3=CC=C(C=C3)C)=O
Molecular Formula
C25H24O7S2
Molecular Weight
500.58
Precautions
H302, H315, H319, H335
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature 3 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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