5,6-Dihydro-2H-pyran-2-one
5,6-Dihydro-2H-pyran-2-one (Compound 1) is a prodrug-type carbonic anhydrase inhibitor. 5,6-Dihydro-2H-pyran-2-one can specifically inhibit the tumor-associated subtype hCA IX and the cytoplasmic subtype hCA I with Ki values of 1.35 and 8.03 μM. 5,6-Dihydro-2H-pyran-2-one can be used for the research on hypoxia-related cancer[1].
Product Specifications
CAS Number
[3393-45-1]
UNSPSC
12352005
Hazard Statement
H226
Target
Carbonic Anhydrase
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Purity
99.19
Smiles
O=C1OCCC=C1
Molecular Formula
C5H6O2
Molecular Weight
98.10
Precautions
H226
References & Citations
[1]Carta F, et al. 5- and 6-membered (thio) lactones are prodrug type carbonic anhydrase inhibitors. Bioorg Med Chem Lett. 2012 Jan 1;22 (1) :267-70.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound2
Clinical Information
No Development Reported
Isoform
CA I; CA IX
Available Sizes
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