FS102
FS102 is a selective Fc fragment with antigen binding (Fcab) that targets HER2 with a KD value of 0.8 nM. FS102 induces the degradation of HER2, activates Caspase 3/7 and disrupts the integrity of the cell membrane, triggering apoptosis of tumor cells. FS102 is promising for research of cancers such as breast cancer, gastric cancer, and colorectal cancer[1][2].
Product Specifications
Product Name Alternative
BMS-986186
UNSPSC
12352203
Target
Caspase; EGFR
Related Pathways
Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
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References & Citations
[1]Batey S, et al. Abstract B123: Preclinical evaluation of FS102: A HER2-specific Fcab with a novel mechanism of action[J]. Molecular Cancer Therapeutics, 2013, 12 (11_Supplement) : B123-B123.|[2]Leung K M, et al. A HER2-specific modified Fc fragment (Fcab) induces antitumor effects through degradation of HER2 and apoptosis[J]. Molecular Therapy, 2015, 23 (11) : 1722-1733.
Shipping Conditions
Room temperature
Scientific Category
Inhibitory Antibodies
Clinical Information
Phase 1
Isoform
Caspase 3; Caspase 7; ErbB2/HER2
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