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Ac-RHKK (Ac) -AMC

Ac-RHKK (Ac) -AMC (Compound S1) is a fluorescent substrate for SITR6, that is based on p53 sequence. Ac-RHKK (Ac) -AMC mimics H3K56 deacetylation site and significantly increases the deacetylation signal with low signal-to-background ratio. Ac-RHKK (Ac) -AMC can be used for ageing and cancers research[1].

Product Specifications

CAS Number

[1193634-36-4]

UNSPSC

12352209

Target

Fluorescent Dye

Related Pathways

Others

Field of Research

Cancer; Metabolic Disease

Smiles

O=C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC1=CNC=N1)C(N[C@@H](CCCCN)C(N[C@@H](CCCCNC(C)=O)C(NC2=CC=C3C(OC(C=C3C)=O)=C2)=O)=O)=O)=O)C

Molecular Formula

C38H56N12O8

Molecular Weight

808.93

References & Citations

[1]Kokkonen P, et al. Studying SIRT6 regulation using H3K56 based substrate and small molecules. Eur J Pharm Sci. 2014 Oct 15;63:71-6.

Shipping Conditions

Room temperature

Scientific Category

Peptides

Clinical Information

No Development Reported

Curated Selection

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