Gypsetin
Gypsetin can inhibit acylcoenzyme A, cholesterol acyltransferase (ACAT) activity, inhibit rat liver microbody ACAT with an IC50 of 18 μM, and its action is competitive with oleoyl-COA substrate, Ki value is 5.5 μM. Gypsetin also inhibits Oleic acid from forming cholesterol esters with an IC50 of 0.65 μM[1].
Product Specifications
CAS Number
155114-38-8
UNSPSC
12352005
Target
Acyltransferase
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Metabolic Disease
Smiles
C=CC(C)([C@]12[C@](C3=CC=CC=C3N1)(C[C@]4([H])N2C([C@@]5([H])N([C@@]6([C@](C5)(C7=CC=CC=C7N6)O)C(C)(C)C=C)C4=O)=O)O)C
Molecular Formula
C32H36N4O4
Molecular Weight
540.65
References & Citations
[1]B Nuber, et al. Gypsetin, a new inhibitor of acyl-CoA: cholesterol acyltransferase produced by Nannizzia gypsea var. incurvata IFO 9228. II. Structure determination. J Antibiot (Tokyo) . 1994 Feb;47 (2) :168-72.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
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