EGTA (tetrasodium)
EGTA tetrasodium is a specific calcium ion chelator. EGTA tetrasodium has an apparent calcium dissociation constant (Kd) of 60.5 nM at physiological pH (7.4) and has very high specificity for Ca2+ over Mg2+ (Mg2+ Kd 1-10 mM) . EGTA tetrasodium significantly inhibits the substrate adherence capacity of inflammatory macrophages[1][2].
Product Specifications
CAS Number
13368-13-3
UNSPSC
12352200
Hazard Statement
H302, H315, H319, H335
Target
Biochemical Assay Reagents
Related Pathways
Others
Field of Research
Inflammation/Immunology
Purity
99.93
Solubility
H2O : 100 mg/mL (ultrasonic)
Smiles
O=C(O[Na])CN(CC(O[Na])=O)CCOCCOCCN(CC(O[Na])=O)CC(O[Na])=O
Molecular Formula
C14H20N2Na4O10
Molecular Weight
468.28
Precautions
H302, H315, H319, H335
References & Citations
[1]Harris RA, Hanrahan JW. Effects of EGTA on calcium signaling in airway epithelial cells. Am J Physiol. 1994;267 (5 Pt 1) :C1426-C1434. doi:10.1152/ajpcell.1994.267.5.C1426.|[2]Segura-Egea JJ, Jiménez-Rubio A, Rios-Santos JV, Velasco-Ortega E, Calvo-Gutierrez JR. In vitro inhibitory effect of EGTA on macrophage adhesion: endodontic implications. J Endod. 2003;29 (3) :211-213.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Biochemical Assay Reagents
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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