Recombinant Human ICOSL Protein (His Tag)

Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains and binds to ICOS on activated T cells, thus delivers a positive costimulatory signal for optimal T cell function. The structural features of ICOSL are crucial for its costimulatory function. The present study shows that ICOSL displays a marked oligomerization potential, resembling more like B7-1 than B7-2. B7-H2-dependent signaling may play an active role in a proliferative response rather than in cytokine and chemokine production. The CD28/B7 and ICOS/B7-H2 pathways are both critical for costimulating T cell immune responses. Deficiency in either pathway results in defective T cell activation, cytokine production, and germinal center formation.

B7H; B7-H; B7 Homolog; B7-Like Protein Gl; B7-Related Protein; V-Set and Immunoglobulin Domain-Containing Protein; KIAA; VSIG; ICOSLG; B7-H2; B7H2; B7RP-1; B7RP1; CD275; GL50; ICOS-L; ICOSL; LICOS; B7 Homolog 2; B7-Like Protein Gl50; B7-Related Protein 1; ICOS Ligand; Protein Z39Ig; V-Set and Immunoglobulin Domain-Containing Protein 4; VSIG4; Z39IG; CRIg; KIAA0653; ICOSL; B7RP1; B7h; B7 H2; B7 homologue 2; B7 like protein Gl50; B7 related protein 1; B7RP 1; CD 275; CD275 antigen; GL 50; ICOS L; ICOS LG; Inducible T cell co stimulator ligand; Transmembrane protein B7 H2 ICOS ligand

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.